Poststimulus afterdischarges of spinal WDR and NS units in rats with chronic nerve constriction
Poststimulus afterdischarges of spinal WDR and NS units in rats with chronic nerve constriction
复制标题
慢性神经收缩大鼠脊髓 WDR 和 NS 单位的刺激后放电
作者：
M. L. Sotgiu;G. Biella;L. Riva
患者;慢性收缩性坐骨神经损伤大鼠背角同时出现40对宽动态范围神经元（WDR）和痛觉特异性神经元（NS）。分析了两种神经元群对有害机械刺激的反应，并比较了后放电情况。出现后放电的神经元数量在WDR人群中高于NS人群。此外，与NS神经元相比，WDR神经元放电后持续时间更长、强度更大、时间衰减更慢。考虑到后放电可能在伤害性信息的长时间传递中所起的作用，我们提出WDR神经元可能对CCI大鼠有害信号的异常处理起重要作用。
&NA; Forty pairs of wide dynamic range (WDR) and nociceptive specific (NS) neurones were simultaneously recorded in the dorsal horn of rats with chronic constriction injury (CCI) of the sciatic nerve. The responses to noxious mechanical stimulation were analysed and the afterdischarges were compared in the two neuronal populations. The number of neurones presenting an afterdischarge was higher in WDR than in NS population. Furthermore afterdischarges had significantly longer duration and greater magnitude with slower time course decays in WDR than in NS neurones. Given the role that afterdischarge may have in the prolonged transmission of nociceptive information, the possibility that WDR neurones could give a major contribute to the abnormal processing of noxious signals in CCI rats is proposed.