Serum levels of soluble CD23 in patients with asthma or rhinitis monosensitive to Parietaria.: Its relation to total serum IgE levels and eosinophil cationic protein during and out of the pollen season
Serum levels of soluble CD23 in patients with asthma or rhinitis monosensitive to Parietaria.: Its relation to total serum IgE levels and eosinophil cationic protein during and out of the pollen season
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DOI：
10.2500/108854199778612590
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发表时间：
1999-03-01
影响因子：
2.8
通讯作者：
Caruso, C
中科院分区：
文献类型：
--
作者：
Di Lorenzo, G;Drago, A;Caruso, C
低亲和力IgE受体及其可溶性循环片段（sCD 23）对过敏的诊断价值尚不清楚。特别是，很少有人知道的季节性影响血清sCD23水平的受试者花粉过敏。在本研究中，为了深入了解sCD 23的病理生理作用，我们分析了对Parietaria sCD 23过敏的患者血液中IgE和嗜酸性粒细胞阳离子蛋白（ECP）血清水平。IgE被评估为特应性标志物，ECP被评估为炎症标志物。在花粉季节期间和花粉季节之外对患者进行了研究，并将结果与非过敏受试者的结果进行了比较。研究人群包括42名不吸烟的门诊患者，居住在Palmero（西西里，意大利）或其他西西西里城镇，临床诊断为季节性哮喘或鼻炎，对Parietaria花粉的皮肤试验呈单阳性。哮喘受试者组由25名仅在花粉季节出现一种或多种常见哮喘症状（喘息、呼吸困难和咳嗽）的患者组成。鼻炎患者组由17名患者组成，他们在花粉季节有鼻部症状（鼻堵塞、打喷嚏、鼻痒和鼻溢），但没有哮喘体征。作为对照组，我们研究了10名实验室工作人员的非特应性受试者。他们没有季节性或常年性鼻炎、哮喘或荨麻疹的病史，对一组过敏症的皮肤试验呈阴性。可溶性CD23，IgE和ECP在血液中进行了评估期间和花粉季节。血清总IgE水平明显高于特应性患者，经典的建立。关于sCD 23血清水平，获得了类似的结果模式。因此，在所有患者组中，sCD 23和IgE水平之间显示出显著相关性。通过分析血清ECP水平，观察到了完全不同的模式，因为ECP水平仅在花粉季节哮喘患者中显着增加。因此，sCD 23水平与ECP水平之间未观察到显著相关性。识别与特应性发展相关的免疫因子可以增强我们对所涉及的体内机制的理解，并且可能在设计用于预防疾病的范例中具有实用性。正如与血清总IgE值密切相关和与血清ECP值缺乏相关性所证明的那样，血清sCD 23水平似乎是诊断特应性的额外标志物，但不用于过敏性疾病的随访。
The diagnostic value for allergies of the low affinity IgE receptor and its soluble circulating fragment (sCD23) remains unclear. In particular, little is know about seasonal influences on serum sCD23 levels in subjects with pollen allergy. In the present study, to gain insight into pathophysiological role of sCD23, we have analyzed, in blood from patients allergic to Parietaria sCD23, IgE, and eosinophil cationic protein (ECP) serum levels. IgE were assessed as atopy markers and ECP as an inflammation marker. Patients were studied during and out of pollen season, and results were compared to those obtained in nonallergic subjects. The study population included 42 nonsmoking outpatients, living in Palmero (Sicily, Italy) or in other west Sicilian towns, with a clinical diagnosis of seasonal asthma or rhinitis and monopositive skin test to Parietaria pollen. The group of asthmatic subjects consisted of 25 patients who had one or more of the usual asthma symptoms (wheezing, dyspnea, and cough) only during the pollen season. The group of rhinitis patients consisted of 17 patients, who, during pollen season, had the nasal symptoms (nasal blockage, sneezing, nasal itching, and rhinorrhoea) but no signs of asthma. As a control group, we studied 10 nonatopic subjects from laboratory staff. They had no history of seasonal or perennial rhinitis, asthma, or urticaria and had negative skin tests to a panel of allergies. Soluble CD23, IgE, and ECP were assessed in blood during and out of pollen season. Total serum IgE levels were clearly higher in atopic patients, as classically established. Concerning sCD23 serum levels, a similar pattern of results was obtained. Accordingly, significant correlations were shown between the levels of sCD23 and IgE in all groups of patients. A completely different pattern was observed by analyzing serum ECP levels because ECP levels were significantly increased only in asthmatic patients during pollen season. Accordingly, no significant correlations were observed between the levels of sCD23 and those of ECP. Identifying immune factors associated with the development of atopy can enhance our understanding of the in vivo mechanisms involved and may have utility in paradigms designed to prevent diseases. As demonstrated by the close correlation with total serum IgE values and the lack of correlation with serum ECP values, serum levels of sCD23 appear to be an additional marker for the diagnosis of atopy but not for the follow-up of allergic diseases.