Olanzapine modulation of long-and short-range functional connectivity in the resting brain in a sample of patients with schizophrenia
Olanzapine modulation of long-and short-range functional connectivity in the resting brain in a sample of patients with schizophrenia
复制标题
奥氮平对精神分裂症患者静息大脑中长程和短程功能连接的调节
DOI：
10.1016/j.euroneuro.2016.11.002
复制
发表时间：
2017-01-01
影响因子：
5.6
通讯作者：
Zhao, Jinping
中科院分区：
文献类型：
--
作者：
Guo, Wenbin;Liu, Feng;Zhao, Jinping
抗精神病药物对脑功能的治疗作用很少被研究。探索无药物精神分裂症患者在抗精神病药物治疗前后的功能连接（FC）可以提高抗精神病药物机制的理解。共有17名复发性精神分裂症患者和24名健康对照者接受了静息态功能磁共振成像扫描。计算每名受试者的长程和短程FC强度（FCS）。与对照组相比，基线时患者双侧顶下小叶（IPL）的长程阳性FCS（IpFCS）增加，大脑默认模式网络（DMN）区域和感觉运动回路的IpFCS减少。相比之下，与对照组相比，在基线时患者右侧IPL中观察到短程阳性FCS增加。奥氮平治疗后，观察到DMN和大脑感觉运动回路中的FC增加，而左侧上级颞回（STG）中的FC减少。此外，治疗后患者的FCS值的变化和症状严重程度的减轻相关。本研究提供的证据表明，奥氮平使精神分裂症患者的长程和短程FC异常正常化。右侧IPL的FC降低可能与早期治疗反应相关，而左侧STG的FC降低可能与不良治疗结局相关。(C)2016 Elsevier B.V.和ECNP。All rights reserved.
Treatment effects of antipsychotic drugs on cerebral function are seldom examined. Exploring functional connectivity (FC) in drug-free schizophrenia patients before and after antipsychotic treatment can improve the understanding of antipsychotic drug mechanisms. A total of 17 drug free patients with recurrent schizophrenia and 24 healthy controls underwent resting-state functional magnetic resonance imaging scans. Long- and short-range FC strengths (FCS) were calculated for each participant. Compared with the controls, the patients at baseline exhibited increased long-range positive FCS (IpFCS) in the bilateral inferior parietal lobule (IPL) and decreased IpFCS in the brain regions of the default-mode network (DMN) regions and sensorimotor circuits of the brain. By contrast, increased short-range positive FCS was observed in the right IPL of the patients at baseline compared with the controls. After treatment with olanzapine, increased FC in the DMN and sensorimotor circuits of the brain was noted, whereas decreased FC was observed in the left superior temporal gyrus (STG). Moreover, the alterations of the FCS values and the reductions in symptom severity among the patients after treatment were correlated. The present study provides evidence that olanzapine normalizes the abnormalities of long-and short-range FCs in schizophrenia. FC reductions in the right IPL may be associated with early treatment response, whereas those in the left STG may be related to poor treatment outcome. (C) 2016 Elsevier B.V. and ECNP. All rights reserved.