Airway Hyperresponsiveness: From Molecules to Bedside Invited Review: The first three minutes: smooth muscle contraction, cytoskeletal events, and soft glasses
Airway Hyperresponsiveness: From Molecules to Bedside Invited Review: The first three minutes: smooth muscle contraction, cytoskeletal events, and soft glasses
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发表时间：
2003
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通讯作者：
S. Gunst;J. Fredberg
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作者：
S. Gunst;J. Fredberg
Gunst，Susan J.，和杰弗里·J·弗雷德伯格特邀评论：前三分钟：平滑肌收缩，细胞骨架事件和软眼镜。J Appl Physiol 95：413-425，2003; 10.1152/japplphysiol. 00277.2003.-平滑肌表现出的生物物理特性和生理行为是不容易解释的细胞骨架和跨桥力学目前的范例。越来越多的证据表明，平滑肌细胞的收缩激活涉及一系列细胞骨架过程，这些过程超出了跨桥循环和粗细细丝的滑动。我们在这里审查的证据表明，平滑肌细胞的生物物理和机械性能反映了集成的相互作用的高度动态的细胞骨架过程，既反应和转换的动态过程中的收缩周期的跨桥相互作用的阵列。平滑肌细胞的激活被提议触发细胞微域内肌动蛋白丝晶格的动态重塑以响应局部机械和药理学事件，使细胞能够适应其外部环境。随着收缩的进行，细胞骨架晶格稳定、固化并形成刚性结构，该刚性结构非常适合于传递由肌球蛋白和肌动蛋白的相互作用产生的张力。发生在收缩周期内的整合分子转换的微尺度搅拌机制和细胞内微环境内产生的重塑事件的背景下进行解释。这样的解释表明，细胞骨架可能表现为玻璃状物质，其机械功能由有效温度控制。
Gunst, Susan J., and Jeffrey J. Fredberg. Invited Review: The first three minutes: smooth muscle contraction, cytoskeletal events, and soft glasses. J Appl Physiol 95: 413–425, 2003; 10.1152/japplphysiol. 00277.2003.—Smooth muscle exhibits biophysical characteristics and physiological behaviors that are not readily explained by present paradigms of cytoskeletal and cross-bridge mechanics. There is increasing evidence that contractile activation of the smooth muscle cell involves an array of cytoskeletal processes that extend beyond cross-bridge cycling and the sliding of thick and thin filaments. We review here the evidence suggesting that the biophysical and mechanical properties of the smooth muscle cell reflect the integrated interactions of an array of highly dynamic cytoskeletal processes that both react to and transform the dynamics of cross-bridge interactions over the course of the contraction cycle. The activation of the smooth muscle cell is proposed to trigger dynamic remodeling of the actin filament lattice within cellular microdomains in response to local mechanical and pharmacological events, enabling the cell to adapt to its external environment. As the contraction progresses, the cytoskeletal lattice stabilizes, solidifies, and forms a rigid structure well suited for transmission of tension generated by the interaction of myosin and actin. The integrated molecular transitions that occur within the contractile cycle are interpreted in the context of microscale agitation mechanisms and resulting remodeling events within the intracellular microenvironment. Such an interpretation suggests that the cytoskeleton may behave as a glassy substance whose mechanical function is governed by an effective temperature.