Taurine: possible role in osmotic regulation of mammalian heart.
Taurine: possible role in osmotic regulation of mammalian heart.
复制标题
牛磺酸：可能在哺乳动物心脏的渗透调节中发挥作用。
DOI：
10.1126/science.7313699
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发表时间：
1981
期刊：
影响因子：
56.9
通讯作者：
E. F. Naccarato
中科院分区：
文献类型：
--
作者：
J. H. Thurston;R. Hauhart;E. F. Naccarato
牛磺酸在海洋无脊椎动物、硬骨鱼和两栖动物细胞内渗透压浓度的维持中起着重要作用。在淡水中，人体组织中的牛磺酸浓度降低；在盐水中，它们会增加。在这项对小鼠的研究中，我们发现在这些哺乳动物适应慢性高钠血症的过程中，心脏的牛磺酸含量增加；其他氨基酸的浓度保持不变或降低。Welty和他的同事已经证明急性低钠血症降低了大鼠心脏的牛磺酸浓度。这些数据一致表明，牛磺酸也可能作为哺乳动物心脏的渗透剂。
It is well established that taurine plays an important role in the maintenance of intracellular osmolal concentration in marine invertebrates, teleosts, and amphibians. In fresh water, concentrations of taurine in body tissues decrease; in salt water, they increase. In this study with mice we found that during adaptation of these mammals to chronic hypernatremia, the taurine content of the heart increased; concentrations of other amino acids were unchanged or were decreased. Welty and his associated have shown that acute hyponatremia lowered the taurine concentration of rat heart. In concert, these data suggest that taurine also may serve as an osmotic agent in mammalian heart.