Label-free detection of amyloid growth with microcantilever sensors
Label-free detection of amyloid growth with microcantilever sensors
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DOI：
10.1088/0957-4484/19/38/384007
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发表时间：
2008-09-24
期刊：
影响因子：
3.5
通讯作者：
Welland, Mark E.
中科院分区：
文献类型：
--
作者：
Knowles, Tuomas P. J.;Shu, Wenmiao;Welland, Mark E.
我们提出了一种使用微悬臂梁系统感测蛋白质聚集的方法。讨论了使用内部参考的单悬臂梁实验和使用专用参考悬臂梁的多悬臂梁阵列测量的结果。我们表明，在这两种情况下，传感器上的蛋白质聚集都可以通过表面应力的相关变化来检测。
We present an approach for sensing protein aggregation using microcantilever systems. Results from both single cantilever experiments with internal reference and multicantilever array measurements with dedicated reference cantilevers are discussed. We show that in both cases protein aggregation on the sensor can be detected through associated changes in surface stress.