Hydrodynamic Forces in Dissecting Aneurysms: In-Vitro Studies in a Tygon Model and in Dog Aortas
Hydrodynamic Forces in Dissecting Aneurysms: In-Vitro Studies in a Tygon Model and in Dog Aortas
复制标题
解剖动脉瘤中的水动力：Tygon 模型和狗主动脉的体外研究
作者：
E. Prokop;R. Palmer;M. Wheat
脉搏波特征被认为是急性夹层动脉瘤扩张和破裂的重要因素。为了验证这一点，建造了一个标准的主动脉模型，由外层的Tygon管子和内层的橡胶粘合剂组成。随着压力的增加，“内膜撕裂”和“主动脉”受到非脉动和脉动血流的影响。在仅有非脉动流的情况下(97个实验)，在压力高达400毫米汞柱的情况下没有发生解剖。脉动血流导致快速且通常完全的夹层，最大收缩压为120毫米汞柱。每脉夹层的程度与液体中的dp/dtmax有关。直到dp/dtmax达到临界值(790毫米汞/秒)，才进行解剖。然后用狗的大动脉代替Tygon管的“大动脉”，结果相似；也就是说，在无脉动的情况下不会发生夹层，但在脉动的情况下(3800毫米汞柱/秒)会发生夹层。夹层的犬主动脉向外破裂或重新进入管腔。结果表明，脉搏波特征，尤其是dp/dtmax，在夹层的传播过程中起着重要作用。
It has been argued that pulse wave characteristics are important factors in extension and rupture of acute dissecting aneurysms. To test this, a standard model of an aorta was constructed, consisting of an outer layer of Tygon tubing and an inner layer of rubber cement. An “intimal tear” was produced and the “aorta” was subjected to nonpulsatile and pulsatile flow with increasing increments of pressure. With nonpulsatile flow alone (97 experiments) no dissection occurred at pressures up to 400 mm Hg. Pulsatile flow produced rapid and usually complete dissection with a maximum systolic pressure of 120 mm Hg. The extent of dissection per pulse was related to dp/dtmax in the fluid. No dissection occurred until a critical value of dp/dtmax (790 mm Hg/sec) was reached. Dog aortas were then used in place of the Tygon tube “aorta” with similar results; i.e., dissection did not occur with nonpulsatile flow, but did occur with pulsatile flow (3800 mm Hg/sec). The dissecting dog aorta ruptured to the outside or reentered the vessel lumen. It was concluded that pulse wave characteristics, particularly dp/dtmax, are important in the propagation of dissection.