Thyrotropin-releasing hormone stimulation and somatostatin inhibition of growth hormone secretion from perfused rat adenohypophyses.
Thyrotropin-releasing hormone stimulation and somatostatin inhibition of growth hormone secretion from perfused rat adenohypophyses.
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促甲状腺激素释放激素刺激和生长抑素抑制灌注大鼠腺垂体分泌生长激素。
DOI：
10.1210/endo-94-6-1709
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发表时间：
1974
期刊：
影响因子：
4.8
通讯作者：
W. Daughaday
中科院分区：
文献类型：
--
作者：
H. Carlson;I. Mariz;W. Daughaday
促甲状腺激素释放激素 (TRH) 导致灌注的大鼠半垂体产生 15-20 分钟的生长激素 (GH) 分泌脉冲。 0.1 ng/ml TRH 的效果虽小但显着，TRH 浓度为 100 ng/ml 时，生长激素分泌增加了 104%。体内或体外用 T3 预处理仅轻微抑制 GH 对 TRH 的反应。茶碱(5.5 ITIM)和二丁酰环AMP(1 mM)均释放GH，而1 mM二丁酰环GMP对GH的分泌没有影响。基础 GH 分泌受到 100 ng/ml 生长抑素的抑制，并且当停止生长抑素时，GH 释放迅速超调；这种“关闭信号”表明在生长抑素给药期间分泌兴奋剂的积累。生长抑素同样可以抑制 TRH 或茶碱引起的 GH 分泌。 (内分泌学 94: 1709, 1974)
Thyrotropin-releasing hormone (TRH) resulted in a 15–20-min pulse of growth hormone (GH) secretion from perfused rat hemipituitaries. Small but significant effects were seen with 0.1 ng/ml TRH, and growth hormone secretion was increased 104% with TRH in a concentration of 100 ng/ml. Pretreatment with T3 in vivo or in vitro resulted in only slight suppression of the GH response to TRH. Theophylline (5.5 ITIM) and dibutyryl cyclic AMP (1 mM) both released GH, while 1 mM dibutyryl cyclic GMP had no effect on the secretion of GH. Basal GH secretion was inhibited by somatostatin, 100 ng/ml, and was followed by a rapid overshoot in GH release when somatostatin was discontinued; this “off signal” suggests the accumulation of a secretory stimulant during somatostatin administration. Somatostatin likewise inhibited GH secretion provoked by TRH or theophyllin. (Endocrinology 94: 1709, 1974)