Factors associated with frailty in Japanese patients with rheumatoid arthritis: results from the Institute of Rheumatology Rheumatoid Arthritis cohort study
Factors associated with frailty in Japanese patients with rheumatoid arthritis: results from the Institute of Rheumatology Rheumatoid Arthritis cohort study
复制标题
日本类风湿性关节炎患者虚弱的相关因素：风湿病研究所类风湿性关节炎队列研究的结果
作者：
T. Furuya;K. Oh;K. Ikari;E. Inoue;E. Tanaka;H. Yamanaka;M. Harigai
本研究旨在评估日本类风湿性关节炎（RA）患者虚弱的患病率及其相关因素。入选风湿性关节炎研究所（IORRA）队列的RA患者完成了自填问卷，其中包括5项虚弱筛选指数。根据虚弱筛选指数的5个组成部分，将患者分类为虚弱、虚弱前期或健壮。Logistic回归分析用于评估临床变量和虚弱之间的关联。在参加这项虚弱研究的3，290例日本RA患者（86.7%为女性，平均年龄62.4岁）中，549例（16.7%）患者被归类为虚弱，2，063例（62.7%）患者被归类为虚弱前期，678例（20.6%）患者被归类为健壮。在多变量模型中，体重指数（BMI）≥ 25 kg/m2（比值比[OR] 1.87，95%置信区间[CI] 1.41至2.47），BMI < 18.5 kg/m2（OR 1.31，95% CI 1.00 - 1.71），28个关节的疾病活动性评分（DAS 28）（OR 1.32，95% CI 1.18 - 1.47），日本版健康评估问卷残疾指数（J-HAQ）（OR 1.26，95% CI 1.04 - 1.52），欧洲五维生活质量量表（EQ-5D）（OR 0.80，95% CI 0.74 - 0.85），使用非甾体抗炎药（NSAID）（OR 1.59，95% CI 1.23 ~ 1.98）和甲氨蝶呤（MTX）使用（OR 0.75，95% CI 0.60 ~ 0.94）与虚弱显著相关（P < 0.05）。BMI（超重和体重不足）、DAS 28、J-HAQ、EQ-5D、NSAID使用和MTX未使用似乎与日本RA患者的虚弱相关。关键点·这是显示RA患者虚弱患病率和相关因素的最大规模研究。维持正常的BMI似乎对预防RA患者的虚弱很重要。·我们证实了日本RA患者的虚弱与高疾病活动性、高残疾程度和健康相关QOL差的显著相关性。·使用NSAID和不使用MTX与日本RA患者的虚弱有关，这可以通过患者的背景来解释。关键点·这是显示RA患者虚弱患病率和相关因素的最大规模研究。维持正常的BMI似乎对预防RA患者的虚弱很重要。·我们证实了日本RA患者的虚弱与高疾病活动性、高残疾程度和健康相关QOL差的显著相关性。·使用NSAID和不使用MTX与日本RA患者的虚弱有关，这可以通过患者的背景来解释。
This study aimed to evaluate the prevalence of, and the factors associated with, frailty in Japanese patients with rheumatoid arthritis (RA). Patients with RA enrolled in the Institute of Rheumatology Rheumatoid Arthritis (IORRA) cohort completed self-administered questionnaires, which included the 5-item frailty screening index. Patients were classified as frail, prefrail, or robust based on the 5 components of the frailty screening index. Logistic regression analyses were used to evaluate associations between clinical variables and frailty. Among 3,290 Japanese patients with RA (86.7% female, mean age 62.4 years) who participated this frailty study, 549 (16.7%) patients were categorized as frailty, 2,063 (62.7%) as prefrailty, and 678 (20.6%) as robust. In multivariable models, body mass index (BMI) ≥ 25 kg/m2 (odds ratio [OR] 1.87, 95% confidence interval [CI] 1.41 to 2.47), BMI < 18.5 kg/m2 (OR 1.31, 95% CI 1.00 to 1.71), disease activity scores in 28 joints (DAS28) (OR 1.32, 95% CI 1.18 to 1.47), Japanese version of Health Assessment Questionnaire disability index (J-HAQ) (OR 1.26, 95% CI 1.04 to 1.52), the European Quality of Life-5 Dimensions (EQ-5D) (OR 0.80, 95% CI 0.74 to 0.85), non-steroidal anti-inflammatory drug (NSAID) use (OR 1.59, 95% CI 1.23 to 1.98), and methotrexate (MTX) use (OR 0.75, 95% CI 0.60 to 0.94) were significantly (P < 0.05) associated with frailty. BMI (both overweight and underweight), DAS28, J-HAQ, EQ-5D, NSAID use, and MTX nonuse appear to be associated with frailty in Japanese patients with RA. Key Points • This is the largest study showing the prevalence and the associated factors of frailty in patients with RA. • Maintaining normal BMI appears to be important for preventing frailty in patients with RA. • We confirmed the significant associations of frailty with high disease activity, high degree of disability, and poor health related QOL in Japanese patients with RA. • NSAID use and MTX nonuse were associated with the frailty in Japanese patients with RA, which could be explained by patients’ background. Key Points • This is the largest study showing the prevalence and the associated factors of frailty in patients with RA. • Maintaining normal BMI appears to be important for preventing frailty in patients with RA. • We confirmed the significant associations of frailty with high disease activity, high degree of disability, and poor health related QOL in Japanese patients with RA. • NSAID use and MTX nonuse were associated with the frailty in Japanese patients with RA, which could be explained by patients’ background.
DOI：
10.1093/gerona/56.3.m146
发表时间：
2001-03-01
影响因子：
5.1
作者：
Fried, LP;Tangen, CM;McBurnie, MA
通讯作者：
McBurnie, MA