Prevention of catheter-associated gram-negative bacilluria with norfloxacin by selective decontamination of the bowel and high urinary concentration.
Prevention of catheter-associated gram-negative bacilluria with norfloxacin by selective decontamination of the bowel and high urinary concentration.
复制标题
通过选择性净化肠道和高尿液浓度，用诺氟沙星预防导管相关的革兰氏阴性菌尿。
DOI：
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发表时间：
1989
影响因子：
5.2
通讯作者：
A. van Griethuysen
中科院分区：
文献类型：
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作者：
E. Vollaard;H. Clasener;J. Zambon;H. Joosten;A. van Griethuysen
口服诺氟沙星预防女性髋部骨折患者的革兰氏阴性杆菌尿，这些患者需要中期经尿管插管。这在一项对34名患者进行的安慰剂对照双盲研究中得到了证实。其中17人接受了含有200毫克诺氟沙星和500毫克两性霉素B的混悬剂，每天两次。在安慰剂组中，到第7天已经发生了6例革兰氏阴性杆菌尿，而药物组在23天的中位导尿期内没有病例发生。在服用安慰剂的第7天，有50%的患者观察到由革兰氏阳性球菌或革兰氏阴性杆菌引起的菌尿；在服用安慰剂的患者中，在第17天观察到这种情况(P<0.001)。随后的革兰氏阳性球菌菌尿被呋喃妥因(50 mg，qid)在四天内消除。诺氟沙星非常适合预防革兰氏阴性杆菌尿，因为它可以净化肠道中的革兰氏阴性杆菌，尿液中的浓度很高，而且很少产生耐药变种。
Oral norfloxacin prevented Gram-negative bacilluria in female patients with hip fractures, who needed medium-term transurethral catheterization. This was shown in a placebo-controlled double-blind study of 34 patients. Seventeen of these received a suspension containing 200 mg norfloxacin and 500 mg amphotericin B, twice daily. In the placebo group, six cases of Gram-negative bacilluria had occurred by day 7, as compared with no cases during a median time of catheterization of 23 days in the group on medication. Bacteriuria, either by Gram-positive cocci or by Gram-negative bacilli, was observed in 50% of patients on placebo by day 7; in the treatment group this was the case by day 17 (P less than 0.001). Subsequent bacteriuria with Gram-positive cocci was eliminated by nitrofurantoin (50 mg qid) within four days. Norfloxacin is very suitable for the prevention of Gram-negative bacilluria, because it decontaminates Gram-negative bacilli from the bowel, reaches high concentrations in urine and rarely produces resistant variants.