New Treatments for Rhabdomyosarcoma: the Importance of Target Practice.

New Treatments for Rhabdomyosarcoma: the Importance of Target Practice.
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横纹肌肉瘤的新治疗方法:靶向治疗的重要性。

DOI:
10.1158/1078-0432.ccr-11-2832
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发表时间:
2012
期刊:
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子:
--
通讯作者:
Barr,FredericG
Barr,FredericG
中科院分区:
--
文献类型:
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作者:
Barr,FredericG

文献摘要

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To address the poor outcomes in rhabdomyosarcoma, particularly the alveolar subtype, new therapies are needed. Potential cancer-specific alterations that may be molecular targets include gene fusions or copy number changes. Following the latter strategy, an attractive antigene approach was developed to inhibitMYCNoncogene expression in rhabdomyosarcoma.Clin Cancer Res; 18(3); 595–7. ©2011 AACR.