Gestational hyperglycemia, zinc, selenium, and antioxidant vitamins
Gestational hyperglycemia, zinc, selenium, and antioxidant vitamins
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DOI：
10.1016/j.nut.2004.05.022
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发表时间：
2005-02-01
期刊：
影响因子：
4.4
通讯作者：
Pagano, GF
中科院分区：
文献类型：
--
作者：
Bo, S;Lezo, A;Pagano, GF
目的：硒和维生素E水平较低已被描述为妊娠糖尿病，一种类似于2型糖尿病的疾病，但关于锌（已知与糖尿病相关）和妊娠高血糖症的数据很少。本研究评估了膳食摄入的抗氧化剂维生素，锌，硒，血清中的锌和硒的水平与妊娠期高血糖症和normocellular.Methods：食物频率问卷调查表进行了管理，以504名孕妇（210与高血糖症和294与normocellular.Methods）。在第二个队列的71高血糖和123 normoglycemic妇女，平均年龄和体重指数相似的第一cohol.Results：膳食摄入量的锌和硒显着降低高血糖患者在怀孕期间的血清锌和硒的水平进行了分析。在多元逻辑回归分析中，经过多重校正后，摄入量与妊娠期高血糖呈负相关（锌和硒的比值比分别为0.89和0.97）。维生素摄入量没有显著差异。在第二个队列的194例患者中，在多元逻辑回归模型中，糖耐量受损患者的血清锌和硒水平显著较低，且与妊娠期高血糖呈负相关（血清锌和血清硒的比值比分别为0.93和0.92）。我们的数据表明，膳食摄入量和血清锌和硒水平与妊娠期高血糖症显着负相关。如果未来的研究证实这些结果，这可能是一个有用的干预方法，适当的饮食咨询，以评估可能减少妊娠代谢异常及其不良后果。(c)2005年爱思唯尔公司All rights reserved.
Objective: Lower levels of selenium and vitamin E have been described in gestational diabetes, a condition similar to type 2 diabetes, but few data are available about zinc (known to be associated with diabetes) and gestational hyperglycemia. This study evaluated the dietary intake of antioxidant vitamins, zinc, selenium, and serum levels of zinc and selenium in women with gestational hyperglycemia and normoglycemia.Methods: A food-frequency questionnaire was administered to 504 pregnant women (210 with hyperglycemia and 294 with normoglycemia). Serum levels of zinc and selenium were analyzed during pregnancy in a second cohort of 71 hyperglycemic and 123 normoglycemic women, with a mean age and body mass index similar to those in the first cohort.Results: Dietary intakes of zinc and selenium were significantly lower in hyperglycemic patients. In multiple logistic regression analysis, intakes were negatively associated with gestational hyperglycemia (odds ratios of 0.89 for zinc and 0.97 for selenium) after multiple adjustments. There were no significant differences in vitamin intakes. In the second cohort of 194 patients, serum levels of zinc and selenium were significantly lower in patients who had impaired glucose tolerance and negatively associated with gestational hyperglycemia in a multiple logistic regression model (odds ratios of 0.93 for serum zinc and 0.92 for serum selenium).Conclusions: Our data suggested a significant inverse association of dietary intakes and serum levels of zinc and selenium with gestational hyperglycemia. If future studies confirm these results, it might be a useful interventional approach to appropriate dietary counseling in order to evaluate the possible decrease in gestational metabolic abnormalities and their adverse consequences. (c) 2005 Elsevier Inc. All rights reserved.