Woringer–Kolopp (localized pagetoid reticulosis) treated with topical photodynamic therapy (PDT)
Woringer–Kolopp (localized pagetoid reticulosis) treated with topical photodynamic therapy (PDT)
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采用局部光动力疗法 (PDT) 治疗 Woringer-Kolopp（局部佩吉样网状组织增生症）
DOI：
10.1111/j.1365-2230.2005.01783.x
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
S. Ibbotson
中科院分区：
文献类型：
--
作者：
L. Berroeta;M. Lewis‐Jones;A. Evans;S. Ibbotson
但是有一些色素沉着。由于Koebnerization，供体区域出现部分色素沉着（图1c）。患者给予甲氧沙林口服20毫克，每周3次，接受区和供体区均予阳光照射。2000年8月，她再次接受了检查。受体区域变暗以匹配周围皮肤（图1b）。供体区域的治疗必须再持续3个月才能完全恢复。她最后一次随访是在2002年，在受体和供体部位都保留了色素。Koebner现象被定义为在特定创伤（如割伤、烧伤或擦伤）的部位出现白癜风斑疹。流行病学研究表明，它发生在大多数患者中，范围从21%到60%以上。它常见于进行性白癜风，也见于单侧白癜风。我们提出了一个罕见的事件，尽管供体部位Koebnerization与白癜风，受体区域完全重新着色在一个病人和第二个病人达到70%的重新着色。在稳定节段性白癜风中很难解释这一点。从这种观察中产生了各种各样的问题。虽然在临床和组织学上，远处的皮肤色素沉着看起来是正常的，但在仔细检查下，在正常的皮肤色素沉着中观察到组织学变化。因此，白癜风患者的色素皮肤可能不像以前认为的那样健康。这种观察是否适用于节段性白癜风，这被认为是神经病理和应该是局部的？在临床稳定的情况下，节段性白癜风的病变可以在病理上活跃吗？由临床医生和科学家进行的协调研究也许能够找到这些问题的答案。
but with some hypopigmentation. The donor area showed partial depigmentation as a result of Koebnerization (Fig. 1c). She was given oral Methoxsalen 20 mg three times a week with sun exposure for recipient and donor areas. She was reexamined in August 2000. The recipient area darkened to match the surrounding skin (Fig. 1b). Treatment for the donor area had to be continued for 3 months more for full recovery. She was last followed up in 2002 and had retained the pigment at both recipient and donor sites. Koebner’s phenomenon is defined as the development of vitiligo macules at the site of specific trauma such as a cut, burn or abrasion. Epidemiological studies indicate that it occurs in a majority of patients ranging from 21% to more than 60%. It is common in progressive vitiligo and is also observed in unilateral vitiligo. We present a rare event in which in spite of Koebnerization of the donor site with vitiligo, the recipient area re-pigmented completely in one patient and a second patient achieved 70% repigmentation. It is difficult to explain this in stable segmental vitiligo. Various questions arise from this observation. Though clinically and histologically, pigmented skin at the distant site appears normal, under close scrutiny histological variations are observed in the normal appearing, pigmented skin. Therefore, pigmented skin of patients with vitiligo may not be as healthy as previously assumed. Does this observation apply to segmental vitiligo, which is considered to be of neural pathology and supposed to be localized? Can the lesions of segmental vitiligo be pathologically active, in spite of clinical stability? A coordinated research conducted by a clinician and a scientist may be able to find answers to these questions.