Pleiotropic roles of Runx transcription factors in the differentiation and function of T lymphocytes
Pleiotropic roles of Runx transcription factors in the differentiation and function of T lymphocytes
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DOI：
10.2174/157339508784325073
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发表时间：
2008-05-01
影响因子：
--
通讯作者：
Satake, Masanobu
中科院分区：
文献类型：
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作者：
Kohu, Kazuyoshi;Kubo, Masato;Satake, Masanobu
RUNX基因家族蛋白是调节T淋巴细胞分化和功能的最重要的转录因子之一。RUNX1和Runx3各自参与了T细胞分化过程中多个不同的步骤。RUNX基因的靶向破坏或转基因过表达会导致多效性和病理表型，包括细胞分化停滞、异常生长或存活和免疫紊乱。RUNX蛋白对多种可能的靶基因的转录产生积极或消极的影响，这取决于启动子、增强子和沉默因子的上下文。现在我们对RUNX的功能有了一个基本的了解。为了充分了解T淋巴细胞的分化和功能，下一个挑战将是研究RUNX作为调节网络的成员，如何与TCR/细胞因子受体信号和其他转录相关因子协同工作。
The proteins of the Runx gene family are among the most important transcription factors for regulating the differentiation and function of T lymphocytes. Runx1 and Runx3 are each involved in multiple and distinct steps throughout the process of T-cell differentiation. Targeted disruption or transgenic overexpression of the Runx genes causes pleiotropic and pathological phenotypes, including cell differentiation arrest, abnormal growth or survival, and immunological disorders. Runx proteins exert positive or negative effects on the transcription of a variety of possible target genes, depending on the context of the promoter, enhancer, and silencer. We now have a basic understanding of Runx function. To fully understand T-lymphocyte differentiation and function, the next challenge will be to investigate how Runx, as a member of a regulatory network, works in cooperation with TCR/cytokine receptor signaling and other transcription-related factors.