An Insight into the Diverse Roles of Surfactant Proteins, SP-A and SP-D in Innate and Adaptive Immunity.
An Insight into the Diverse Roles of Surfactant Proteins, SP-A and SP-D in Innate and Adaptive Immunity.
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DOI：
10.3389/fimmu.2012.00131
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发表时间：
2012
影响因子：
7.3
通讯作者：
Kishore U
中科院分区：
文献类型：
--
作者：
Nayak A;Dodagatta-Marri E;Tsolaki AG;Kishore U
表面活性蛋白SP-A和SP-D是亲水性的、含胶原的钙依赖性凝集素，其似乎在肺以及肺外部位具有一系列先天免疫功能。这些蛋白质通过C-末端同源三聚体碳水化合物识别结构域与病原体、过敏原和凋亡细胞上的靶配体结合，而胶原蛋白区域通过其与细胞表面受体的相互作用产生效应子功能。SP-A和SP-D利用一系列先天免疫机制（如凝集/聚集、增强吞噬作用、吞噬细胞杀伤机制和直接生长抑制）处理各种病原体。SP-A和SP-D也被证明参与控制肺部炎症，包括过敏和哮喘。新出现的证据表明，SP-A和SP-D能够将先天免疫与获得性免疫联系起来，包括调节树突状细胞功能和辅助T细胞极化。本文综述了SP-A和SP-D在肺内外的免疫学特性，并讨论了它们在人类健康和疾病中的重要性。
Surfactant proteins SP-A and SP-D are hydrophilic, collagen-containing calcium-dependent lectins, which appear to have a range of innate immune functions at pulmonary as well as extrapulmonary sites. These proteins bind to target ligands on pathogens, allergens, and apoptotic cells, via C-terminal homotrimeric carbohydrate recognition domains, while the collagen region brings about the effector functions via its interaction with cell surface receptors. SP-A and SP-D deal with various pathogens, using a range of innate immune mechanisms such as agglutination/aggregation, enhancement of phagocytosis, and killing mechanisms by phagocytic cells and direct growth inhibition. SP-A and SP-D have also been shown to be involved in the control of pulmonary inflammation including allergy and asthma. Emerging evidence suggest that SP-A and SP-D are capable of linking innate immunity with adaptive immunity that includes modulation of dendritic cell function and helper T cell polarization. This review enumerates immunological properties of SP-A and SP-D inside and outside lungs and discusses their importance in human health and disease.