Human Coronaviruses: A Review of Virus-Host Interactions.
Human Coronaviruses: A Review of Virus-Host Interactions.
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DOI：
10.3390/diseases4030026
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发表时间：
2016-07-25
期刊：
影响因子：
--
通讯作者：
Liu DX
中科院分区：
文献类型：
--
作者：
Lim YX;Ng YL;Tam JP;Liu DX
人类冠状病毒（hcov）是已知的与一系列呼吸道疾病相关的呼吸道病原体。在过去的14年中，严重急性呼吸综合征冠状病毒（SARS-CoV）和中东呼吸综合征冠状病毒（MERS-CoV）的发病使hcov因其对人类的高致病性而成为研究界的焦点。HCoV-宿主相互作用的研究为我们对HCoV发病机制的理解做出了广泛贡献。在这篇综述中，我们讨论了一些最近发现的宿主细胞因子，这些因子可能被hcov利用来促进自身的复制周期。我们还讨论了各种可能被hcov调节的细胞过程，如凋亡、先天免疫、内质网应激反应、丝裂原活化蛋白激酶（MAPK）途径和核因子κB （NF-κB）途径。
Human coronaviruses (HCoVs) are known respiratory pathogens associated with a range of respiratory outcomes. In the past 14 years, the onset of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) have thrust HCoVs into spotlight of the research community due to their high pathogenicity in humans. The study of HCoV-host interactions has contributed extensively to our understanding of HCoV pathogenesis. In this review, we discuss some of the recent findings of host cell factors that might be exploited by HCoVs to facilitate their own replication cycle. We also discuss various cellular processes, such as apoptosis, innate immunity, ER stress response, mitogen-activated protein kinase (MAPK) pathway and nuclear factor kappa B (NF-κB) pathway that may be modulated by HCoVs.