Prematurity Is Not Associated with Reduced Insulin Sensitivity in Adulthood
Prematurity Is Not Associated with Reduced Insulin Sensitivity in Adulthood
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DOI：
10.1210/jc.2008-1769
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发表时间：
2009-05-01
影响因子：
5.8
通讯作者：
Hokken-Koelega, Anita C. S.
中科院分区：
文献类型：
--
作者：
Willemsen, Ruben H.;Leunissen, Ralph W. J.;Hokken-Koelega, Anita C. S.
背景：2005年，12.7%的婴儿早产，而且发生率还在上升。如今，由于存活率的提高，越来越多的早产儿达到了年轻的成年期。最近的一份报告表明，早产儿童对胰岛素的敏感度较低，这可能会使他们面临患2型糖尿病的风险。然而，目前尚不清楚这种胰岛素敏感性降低是否会持续到成年。方法：我们用频繁采样的静脉葡萄糖耐量试验测定了305名年轻人(18-24岁；169名早产儿和136名足月儿)的胰岛素敏感性和β细胞功能。用双能X线骨密度仪测量成人的身体成分。我们调查了胎龄、出生时大小和成人身体成分对胰岛素敏感性的影响。结果：与以往的报道相反，我们没有发现早产对青年胰岛素敏感性有有害影响的证据。成人躯干脂肪和女性口服避孕药的使用是胰岛素不敏感的最重要的决定因素，与出生时的大小和孕期无关。结论：与我们的假设相反，早产与年轻成年时胰岛素敏感性降低无关。(临床内分泌代谢酶94：1695-1700,2009)
Background: In 2005, 12.7% of all babies were born preterm, and the incidence is rising. Nowadays, due to improved survival, an increasing number of children born preterm reach young adulthood. A recent report suggested lower insulin sensitivity in children born preterm, which may put them at risk for the development of type 2 diabetes. It is, however, still unknown whether this reduced insulin sensitivity persists into adulthood.Methods: We determined insulin sensitivity and beta-cell function with frequently sampled iv glucose tolerance tests in 305 young adults (aged 18-24 yr; 169 preterm and 136 term). Adult body composition was measured by dual energy x-ray absorptiometry. We investigated the effect of gestational age, size at birth, and adult body composition on insulin sensitivity.Results: In contrast to previous reports, we found no evidence that preterm birth has a deleterious effect on insulin sensitivity in young adulthood. Adult trunk fat and the use of oral contraceptives in women were the most important determinants of insulin insensitivity, independently of size at birth and duration of pregnancy.Conclusion: Contrary to our hypothesis, preterm birth was not associated with reduced insulin sensitivity in young adulthood. (J Clin Endocrinol Metab 94: 1695-1700, 2009)