Tuberculosis and airflow obstruction: evidence from the PLATINO study in Latin America
Tuberculosis and airflow obstruction: evidence from the PLATINO study in Latin America
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DOI：
10.1183/09031936.00083507
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发表时间：
2007-12-01
影响因子：
24.3
通讯作者：
Victora, C. G.
中科院分区：
文献类型：
--
作者：
Menezes, A. M. B.;Hallal, P. C.;Victora, C. G.
这项研究的目的是评估肺结核病史和气流阻塞之间的关系。一项以人群为基础的多中心研究包括5571名年龄=40岁的受试者，他们生活在拉丁美洲五个大都市之一：圣保罗(巴西)、蒙得维的亚(乌拉圭)、墨西哥城(墨西哥)、圣地亚哥(智利)和加拉加斯(委内瑞拉)。受试者在服用支气管扩张剂前后进行肺活量测定，并被问及他们是否曾被医生诊断为肺结核。在有肺结核病史的患者中，气流阻塞(一秒内用力呼气量/服用支气管扩张剂后的用力肺活量)的总体患病率为30.7%，而在无肺结核病史的患者中，这一比例为13.9%。有肺结核病史的男性出现气流阻塞的可能性是那些没有这种诊断的男性的4.1倍。在对年龄、性别、教育程度、种族、吸烟、接触粉尘和烟雾、儿童呼吸道发病率和目前发病率进行混杂调整后，这一数字保持不变。在女性中，未调整和调整后的优势比分别为2.3和1.7。总而言之，在拉丁美洲中老年人中，肺结核病史与气流障碍有关。
The aim of the present study was to evaluate the association between history of tuberculosis and airflow obstruction.A population-based, multicentre study was carried out and included 5,571 subjects aged >= 40 yrs living in one of five Latin American metropolitan areas: Sao Paulo (Brazil); Montevideo (Uruguay); Mexico City (Mexico); Santiago (Chile); and Caracas (Venezuela). Subjects performed pre- and post-bronchodilator spirometry and were asked whether they had ever been diagnosed with tuberculosis by a physician.The overall prevalence of airflow obstruction (forced expiratory volume in one second/forced vital capacity post-bronchodilator < 0.7) was 30.7% among those with a history of tuberculosis, compared with 13.9% among those without a history. Males with a medical history of tuberculosis were 4.1 times more likely to present airflow obstruction than those without such a diagnosis. This remained unchanged after adjustment for confounding by age, sex, schooling, ethnicity, smoking, exposure to dust and smoke, respiratory morbidity in childhood and current morbidity. Among females, the unadjusted and adjusted odds ratios were 2.3 and 1.7, respectively.In conclusion, history of tuberculosis is associated with airflow obstruction in Latin American middle-aged and older adults.