Leukocyte telomere length and cardiovascular disease in the cardiovascular health study
Leukocyte telomere length and cardiovascular disease in the cardiovascular health study
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DOI：
10.1093/aje/kw346
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发表时间：
2007-01-01
影响因子：
5
通讯作者：
Aviv, Abraham
中科院分区：
文献类型：
--
作者：
Fitzpatrick, Annette L.;Kronmal, Richard A.;Aviv, Abraham
复制体细胞的端粒长度与年龄呈负相关，并已被报道与心血管疾病（CVD）相关。测量了心血管健康研究中随机选择的419名参与者的白细胞端粒长度（以平均末端限制性片段（TRF）长度表示），该研究包括在美国四个社区招募的社区居民队列。作者调查了TRF长度与亚临床CVD/CVD风险因素（数据收集于1992/1993年门诊访视）和CVD事件（确定至2002年6月）的选定测量值之间的相关性。在这些参与者中（平均年龄= 74.2岁（标准差，5.2）），平均TRF长度为6.3个酶对（标准差，0.62）。TRF长度与糖尿病、血糖、胰岛素、舒张压、颈动脉内膜中层厚度和白细胞介素-6之间存在显著或临界负相关。与体型和C反应蛋白的关联因性别和年龄而改变，仅发生在男性和73岁或以下的参与者中。在年轻（而非老年）参与者中，TRF的每个缩短的酶对对应于心肌梗死（风险比= 3.08，95%置信区间：1.22，7.73）和中风（风险比= 3.22，95%置信区间：1.29，8.02）的风险增加3倍。这些结果支持了端粒磨损可能通过氧化应激、炎症和进展为CVD的机制与衰老疾病相关的假设。
The telomere length of replicating somatic cells is inversely correlated with age and has been reported to be associated cross-sectionally with cardiovascular disease (CVD). Leukocyte telomere length, as expressed by mean terminal restriction fragment (TRF) length, was measured in 419 randomly selected participants from the Cardiovascular Health Study, comprising a community-dwelling cohort recruited in four US communities. The authors investigated associations between TRF length and selected measures of subclinical CVD/risk factors for CVD (data were collected at the 1992/1993 clinic visit) and incident CVD (ascertained through June 2002). In these participants (average age = 74.2 years (standard deviation, 5.2)), mean TRF length was 6.3 kilobase pairs (standard deviation, 0.62). Significant or borderline inverse associations were found between TRF length and diabetes, glucose, insulin, diastolic blood pressure, carotid intima-media thickness, and interleukin-6. Associations with body size and C-reactive protein were modified by gender and age, occurring only in men and in participants aged 73 years or younger. In younger (but not older) participants, each shortened kilobase pair of TRF corresponded with a threefold increased risk of myocardial infarction (hazard ratio = 3.08, 95% confidence interval: 1.22, 7.73) and stroke (hazard ratio = 3.22, 95% confidence interval: 1.29, 8.02). These results support the hypotheses that telomere attrition may be related to diseases of aging through mechanisms involving oxidative stress, inflammation, and progression to CVD.