Novel Organization of the Arginine Catabolic Mobile Element and Staphylococcal Cassette Chromosome mec Composite Island and Its Horizontal Transfer between Distinct Staphylococcus aureus Genotypes
Novel Organization of the Arginine Catabolic Mobile Element and Staphylococcal Cassette Chromosome mec Composite Island and Its Horizontal Transfer between Distinct Staphylococcus aureus Genotypes
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DOI：
10.1128/aac.01321-13
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发表时间：
2013-11-01
影响因子：
4.9
通讯作者：
Friedrich, Alexander W.
中科院分区：
文献类型：
--
作者：
Sabat, Artur J.;Koeck, Robin;Friedrich, Alexander W.
在这项研究中，425耐甲氧西林金黄色葡萄球菌（MRSA）分离株回收的荷兰-德国Euregio的精氨酸分解代谢移动的元素（ACME）的存在进行了调查。通过全基因组测序的序列分析揭示了ACME-葡萄球菌盒式染色体mec复合岛（SCCmec-CI）的全新组织，其中截短的ACME II型位于SCCmec的下游。ACME-SCCmec-CI在两个不同的MRSA谱系（t064-ST 8和t002-ST 5）中发现了相同的核苷酸序列，这在以前的S.金黄色。
In this study, 425 methicillin-resistant Staphylococcus aureus (MRSA) isolates recovered in the Dutch-German Euregio were investigated for the presence of the arginine catabolic mobile element (ACME). Sequence analysis by whole-genome sequencing revealed an entirely new organization of the ACME-staphylococcal cassette chromosome mec composite island (SCCmec-CI), with truncated ACME type II located downstream of SCCmec. An identical nucleotide sequence of ACME-SCCmec-CI was found in two distinct MRSA lineages (t064-ST8 and t002-ST5), which has not been reported previously in S. aureus.