μ opioid receptor knockout in mice:: effects on ligand-induced analgesia and morphine lethality
μ opioid receptor knockout in mice:: effects on ligand-induced analgesia and morphine lethality
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DOI：
10.1016/s0169-328x(97)00353-7
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发表时间：
1998-03-01
期刊：
影响因子：
--
通讯作者：
Wei, LN
中科院分区：
文献类型：
--
作者：
Loh, HH;Liu, HC;Wei, LN
通过基因靶向方法，对小鼠的mu阿片受体基因（MOR）进行突变。在这些morr基因敲除小鼠中，吗啡及其主要代谢物吗啡-6-葡萄糖醛酸盐（M-6-G）和吗啡-6-醚硫酸酯（M-6-S）和内啡肽-2的镇痛作用以及吗啡诱导的致死性显著降低，而DPDPE和U50488的作用保持不变。结论：mu受体介导了mu特异性阿片配体的镇痛作用和急性吗啡致死性。(C) 1998爱思唯尔科学有限公司
The mu opioid receptor gene (MOR) was mutated in mice by a gene targeting procedure. In these MOR-knockout mice, the analgesic effects of morphine, its major metabolites, morphine-6-glucuronide (M-6-G) and morphine-6-ethereal sulfate (M-6-S), and endomorphin-2, as well as morphine-induced lethality, were drastically reduced, whereas the effects of DPDPE and U50488 remained unchanged. It is concluded that analgesic effects of mu-specific opioid ligands and acute morphine lethality are mediated by the mu receptor. (C) 1998 Elsevier Science B.V.