S-antigen immunoreactivity in trilateral retinoblastoma.
S-antigen immunoreactivity in trilateral retinoblastoma.
复制标题
三侧视网膜母细胞瘤中的 S 抗原免疫反应性。
DOI：
10.1016/s0002-9394(14)74170-4
复制
发表时间：
1987
影响因子：
4.2
通讯作者：
Lahoud,S
中科院分区：
文献类型：
--
作者：
Donoso,LA;Rorke,LB;Shields,JA;Augsburger,JJ;Brownstein,S;Lahoud,S
使用单克隆抗体MAbA 9-C6，它确定了一个抗原决定簇的S-抗原保留在固定的组织切片，我们调查了S-抗原免疫反应性的眼和脑肿瘤的四例三侧视网膜母细胞瘤。在眼睛中，S-抗原免疫反应存在于所有视网膜母细胞瘤检查，以及一个视网膜细胞瘤的特点是良性出现的细胞，包括fleuretettes。S-抗原免疫反应是局灶性存在于两个四个脑肿瘤检查。此外，两个眼内髓上皮瘤，其中一个包含明确的roximus，和16个原发性颅内肿瘤，包括7个松果体肿瘤和9个其他病变，其中一些组织病理学可能类似视网膜母细胞瘤，进行了检查。S-抗原免疫反应观察到两个松果体肿瘤，但没有其余的9个原发性颅内肿瘤或两个眼内髓上皮瘤。我们的研究结果进一步证实了视网膜和松果体之间的免疫关系，肿瘤起源于这些组织。
Using monoclonal antibody MAbA9-C6, which identifies an antigenic determinant of S-antigen retained in fixed tissue sections, we investigated S-antigen immunoreactivity in the ocular and brain tumors of four cases of trilateral retinoblastoma. In the eye, S-antigen immunoreactivity was present in all retinoblastomas examined, as well as one retinocytoma characterized by benign appearing cells including fleurettes. S-antigen immunoreactivity was focally present in two of the four brain tumors examined. Additionally, two intraocular medulloepitheliomas, one of which contained well-defined rosettes, and 16 primary intracranial tumors, including seven pineal gland tumors and nine other lesions, some of which histopathologically may resemble retinoblastoma, were examined. S-antigen immunoreactivity was observed in two pineal gland tumors but not the remaining nine primary intracranial neoplasms or the two intraocular medulloepitheliomas. Our results further substantiate the immunologic relationship between the retina and the pineal gland, and tumors originating in these tissues.