The social genome of friends and schoolmates in the National Longitudinal Study of Adolescent to Adult Health
The social genome of friends and schoolmates in the National Longitudinal Study of Adolescent to Adult Health
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DOI：
10.1073/pnas.1711803115
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发表时间：
2018-01-23
影响因子：
11.1
通讯作者：
Harris, Kathleen Mullan
中科院分区：
文献类型：
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作者：
Domingue, Benjamin W.;Belsky, Daniel W.;Harris, Kathleen Mullan
人类倾向于与与自己相似的人建立社会关系。这种相似的排序是否源于历史的迁徙模式、现代社会的中观社会结构，还是个人层面对相似同伴的选择，仍然没有定论。最近的研究评估了未观察到的基因型可能在同性关系的创建中发挥重要作用的可能性。我们通过使用国家青少年到成人健康纵向研究 (Add Health) 的 5,500 名青少年的数据来扩展这项工作，以检查朋友之间的遗传相似性。尽管有一些证据表明朋友在全基因组水平以及性状相关基因座（通过多基因评分）上具有相关的基因型，但进一步的分析表明中观水平的力量，例如学校分配，是朋友之间遗传相似性的主要来源。我们还观察到明显的社会遗传效应，其中个人的朋友和同学的多基因分数预测了个人自己的教育程度。相比之下，一个人的身高与同龄人的身高遗传无关。
Humans tend to form social relationships with others who resemble them. Whether this sorting of like with like arises from historical patterns of migration, meso-level social structures in modern society, or individual-level selection of similar peers remains unsettled. Recent research has evaluated the possibility that unobserved genotypes may play an important role in the creation of homophilous relationships. We extend this work by using data from 5,500 adolescents from the National Longitudinal Study of Adolescent to Adult Health (Add Health) to examine genetic similarities among pairs of friends. Although there is some evidence that friends have correlated genotypes, both at the whole-genome level as well as at trait-associated loci (via polygenic scores), further analysis suggests that meso-level forces, such as school assignment, are a principal source of genetic similarity between friends. We also observe apparent socialgenetic effects in which polygenic scores of an individual's friends and schoolmates predict the individual's own educational attainment. In contrast, an individual's height is unassociated with the height genetics of peers.