Calcium homeostasis and intact plasma parathyroid hormone during exercise and training in young Standardbred horses.
Calcium homeostasis and intact plasma parathyroid hormone during exercise and training in young Standardbred horses.
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年轻标准种马运动和训练期间的钙稳态和完整血浆甲状旁腺激素。
DOI：
10.2746/042516402776250379
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发表时间：
2010
影响因子：
2.2
通讯作者：
H. Sporleder
中科院分区：
文献类型：
--
作者：
I. Vervuert;M. Coenen;U. Wedemeyer;C. Chrobok;J. Harmeyer;H. Sporleder
众所周知，体育锻炼会影响马的钙稳态，但关于运动期间钙代谢的激素调节方面的信息很少。为了评价运动和训练对钙稳态和全血甲状旁腺激素的影响，对7匹未经训练的标准马进行了为期6周的训练。这些马在训练开始前3周习惯在跑步机上跑步，并在高速跑步机上进行初始递增标准化运动试验(设置1：6个递增步，每步5min；第一步5m/S，增加1m/S)。SET 1之后是乳酸引导训练方案(共6周)，在每个工作日之后的一天中交替进行两种运动：从VLa4开始的15min的高速运动，每60分钟持续增加0.3m/S(14步)；和VLa2.5恒速的低速运动，持续时间约60-90分钟。整个培训计划包括8个HSE和8个LSE课程。HSE和LSE被计算为需要相同的能量消耗。最后一组(第二组)完成了训练计划。分别于第1、2组，第1、8次HSE和LSE前、中、后，第1、8次HSE和LSE前、中、后，采血测定乳酸、血浆总钙、血钙、血pH、血浆无机磷、血浆全段甲状旁腺激素(PTH)。在组1和组2中，组1和组8的游离钙离子和pH降低，乳酸、完整的甲状旁腺素和P(I)升高。LSE1和LSE8引起pH升高，而乳酸、离子钙、总钙、磷(I)和完整甲状旁腺素(PTH)未受影响。训练过程中未检测到钙代谢的变化。这项研究的结果表明，完整的甲状旁腺激素是运动性低钙血症逆调节的中介。
Physical exercise is known to affect calcium homeostasis in horses, but there is little information on the hormonal regulation of calcium metabolism during exercise. In order to evaluate the effects of exercise and training on calcium homeostasis and intact plasma parathyroid hormone, 7 untrained Standardbred horses were studied in a 6 week training programme. These horses were accustomed to running on the treadmill 3 weeks before onset of training and were exercised on a high-speed treadmill with an initial incremental standardised exercise test (SET 1: 6 incremental steps of 5 min duration each; first step 5 m/s, increase 1 m/s). SET 1 was followed by a lactate-guided training programme (6 weeks in total) with 2 types of exercise in alternating order with a day of rest after each work day: high-speed exercise (HSE) of 15 min duration, starting at VLa4, continuous increase in speed every 60 s by 0.3 m/s (14 incremental steps); and low-speed exercise (LSE) at a constant velocity at VLa2.5, duration approximately 60-90 min. The whole training programme consisted of 8 HSE and 8 LSE sessions. HSE and LSE were calculated to require the same energy expenditure. A final SET (SET 2) finished the training programme. Blood samples for lactate, plasma total calcium [Ca], blood ionised calcium [Ca2+], blood pH, plasma inorganic phosphorus [P(i)] and plasma intact parathyroid hormone [PTH] were collected before, during and after SETs 1 and 2, before and after the first and eighth HSE and LSE. During SETs 1 and 2, HSEs 1 and 8 there was a decrease in ionised Ca2+ and pH and a rise in lactate, intact PTH and P(i). LSEs 1 and 8 resulted in an increase in pH, whereas lactate, ionised Ca2+, total Ca, P(i) and intact PTH were not affected. No changes in calcium metabolism were detected during training. Results of this study suggest that intact PTH is a mediator in counter-regulation of exercise-induced hypocalcaemia.