DNA repair and breast carcinoma susceptibility in women
DNA repair and breast carcinoma susceptibility in women
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DOI：
10.1002/cncr.20135
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发表时间：
2004-04-01
期刊：
影响因子：
6.2
通讯作者：
Matta, JL
中科院分区：
文献类型：
--
作者：
Ramos, JM;Ruiz, A;Matta, JL
背景资料。乳腺癌是最常见的癌症，也是女性癌症相关死亡的第二大原因。这种疾病约占波多黎各妇女所有癌症的31%。有几个DNA修复途径参与了预防癌症的发生。本研究评估了DNA修复能力降低是乳腺癌易感因素的假设。方法：采用回顾性病例对照临床研究，比较33例经组织病理证实的乳腺癌患者(病例)和47例未患乳腺癌的女性(对照组)的年龄匹配情况。用带有荧光素酶报告基因的宿主细胞再激活实验检测DRC，然后将其导入人外周淋巴细胞。结果：乳腺癌患者的平均DRC为5.6%+/-0.5标准差(SEM)。与对照组(DRC=8.7%+/-0.7SEM)相比，癌症患者的DRC减少了36%(P<；0.001)。研究发现，与年龄匹配的对照组相比，年轻乳腺癌患者的DRC有更显著的降低。家族史(优势比[OR]=4.1)、母系(OR=5.5)和母史(OR=12.4)是与乳腺癌发病相关的唯一有统计学意义(P<；0.05)的危险因素。DRC每减少1%，乳腺癌风险就增加22%。据作者所知，目前的研究是第一次直接确定乳腺癌女性的DRC。由于DRC是乳腺癌的独立危险因素，因此女性DRC可能是预测乳腺癌易感性的有用标记物。(C)2004年美国癌症协会。
BACKGROUND. Breast carcinoma is the most common cancer and the second leading cause of cancer-related deaths among women. The disease represents approximately 31% of all cancers in Puerto Rican women. Several DNA repair pathways are involved in preventing carcinogenesis. The current study evaluated the hypothesis that a reduced DNA repair capacity (DRC) is a susceptibility factor for breast carcinoma.METHODS. A retrospective case-control clinical study was performed to compare age-matched DRC in 33 women with histopathologically confirmed breast carcinoma (cases) and 47 cancer-free women (controls). DRC was measured using a host cell reactivation assay with a luciferase reporter gene and then transfected into human peripheral lymphocytes. A questionnaire was used to solicit breast carcinoma risk factors.RESULTS. Women with breast carcinoma had a mean DRC of 5.6% +/- 0.5 standard error of the mean (SEM). Cancer cases had a 36% reduction (P < 0.001) in DRC when compared with the control group (DRC = 8.7% +/- 0.7 SEM). Younger participants with breast carcinoma were found to have a more significant reduction in DRC when compared with age-matched controls. Family (odds ratio [OR] = 4.1), maternal lineage (OR = 5.5), and maternal (OR = 12.4) history of breast carcinoma were found to be the only statistically significant (P < 0.05) risk factors associated with the disease.CONCLUSIONS. The findings supported the hypothesis that a low DRC is a susceptibility factor for breast carcinoma. A 1% decrease in DRC corresponded to a 22% increase in breast carcinoma risk. To the authors' knowledge, the current study was the first to directly determine the DRC of women with breast carcinoma. Because DRC is an independent risk factor for breast carcinoma, the DRC of women may be a useful marker in predicting susceptibility. (C) 2004 American Cancer Society.