Prognostic value of histopathological regression in 850 neoadjuvantly treated oesophagogastric adenocarcinomas.
Prognostic value of histopathological regression in 850 neoadjuvantly treated oesophagogastric adenocarcinomas.
复制标题
DOI：
10.1038/bjc.2014.94
复制
发表时间：
2014-04-02
影响因子：
8.8
通讯作者：
Ott, K.
中科院分区：
文献类型：
--
作者：
Schmidt, T.;Sicic, L.;Blank, S.;Becker, K.;Weichert, W.;Bruckner, T.;Parakonthun, T.;Langer, R.;Buechler, M. W.;Siewert, J-R;Lordick, F.;Ott, K.
关键词：
最近，组织病理学肿瘤消退，印戒细胞的患病率，和本地化作为预后因素，在新治疗的食管胃（交界和胃）癌。这项探索性回顾性研究分析了术前化疗后大型患者队列中的独立预后因素，包括临床和组织病理学因素。总共有850例cT 3/4 Nany cM 0/x期食管胃癌患者在两个学术中心接受了新辅助化疗，然后进行了切除术。患者数据记录在前瞻性数据库中，并进行回顾性分析。在单因素分析的所有预后因素中，只有临床反应、并发症、ypTNM分期和R分类是多因素分析的独立预后因素（P<0.01）。肿瘤定位和印戒细胞是独立的预后，只有当肿瘤依赖性临床反应的评估被排除在多变量模型。组织学肿瘤消退与肿瘤分级、Laurén分类、临床缓解、ypT、ypN和R分类相关，但未被确定为独立的预后因素。在R 0切除患者中，只有手术并发症和ypTNM分期是独立的预后因素。只有确定的预后因素，如ypTNM分期，R分类和并发症被确定为新辅助化疗后切除患者的独立预后因素。与此相反，组织病理学肿瘤消退没有被发现作为一个独立的预后指标。
Recently, histopathological tumour regression, prevalence of signet ring cells, and localisation were reported as prognostic factors in neoadjuvantly treated oesophagogastric (junctional and gastric) cancer. This exploratory retrospective study analyses independent prognostic factors within a large patient cohort after preoperative chemotherapy including clinical and histopathological factors. In all, 850 patients presenting with oesophagogastric cancer staged cT3/4 Nany cM0/x were treated with neoadjuvant chemotherapy followed by resection in two academic centres. Patient data were documented in a prospective database and retrospectively analysed. Of all factors prognostic on univariate analysis, only clinical response, complications, ypTNM stage, and R category were independently prognostic (P<0.01) on multivariate analysis. Tumour localisation and signet ring cells were independently prognostic only when investigator-dependent clinical response evaluation was excluded from the multivariate model. Histopathological tumour regression correlates with tumour grading, Laurén classification, clinical response, ypT, ypN, and R categories but was not identified as an independent prognostic factor. Within R0-resected patients only surgical complications and ypTNM stage were independent prognostic factors. Only established prognostic factors like ypTNM stage, R category, and complications were identified as independent prognostic factors in resected patients after neoadjuvant chemotherapy. In contrast, histopathological tumour regression was not found as an independent prognostic marker.
登录
查看更多内容
DOI：
10.1007/s10120-003-0245-4
发表时间：
2003-01-01
期刊：
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
影响因子：
--
作者：
Ott, Katja;Sendler, Andreas;Fink, Ulrich
通讯作者：
Fink, Ulrich
影响因子：
0.3
作者：
Bader, Franz G.;Lordick, Florian;Ott, Katja
通讯作者：
Ott, Katja
影响因子：
3.8
作者：
Heidecke, CD;Weighardt, H;Holzmann, B
通讯作者：
Holzmann, B
影响因子：
3.7
作者：
Mansour, John C.;Tang, Laura;Coit, Daniel G.
通讯作者：
Coit, Daniel G.
影响因子：
3.7
作者：
Reim, Daniel;Gertler, Ralf;Schumacher, Christoph
通讯作者：
Schumacher, Christoph