Paternal periconception metabolic health and offspring programming.
Paternal periconception metabolic health and offspring programming.
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DOI：
10.1017/s0029665121003736
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发表时间：
2021-10
期刊：
影响因子：
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通讯作者：
Nader Eid;Hannah L Morgan;A. Watkins
中科院分区：
文献类型：
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作者：
Nader Eid;Hannah L Morgan;A. Watkins
母体在受孕时的代谢状态与随后的胚胎发生和后代发育之间的关系已被详细研究。然而，很少有人注意到父亲的营养和代谢在指导后代健康方面的意义。尽管存在这种差异，但新出现的证据已经开始强调父亲代谢健康、精液质量、胚胎发育和最终成年后代健康之间的重要联系。这在健康和疾病的发展起源假说中建立了一个新的组成部分。基于数十年来从众多孕产妇规划模式中获得的理解和见解，现在的注意力正集中于确定父亲福祉、受精后发育和后代健康之间联系的潜在机制。了解父亲的健康状况对精液质量的影响，对于向准父亲提供更好的信息至关重要。此外，辅助生殖实践，如体外受精，依赖于我们从多样化和异质人群中选择最优质精子的能力。近年来，随着测序能力的显著进步，我们对精子和精浆的分子和表观遗传组成及其与男性代谢健康的关系的理解有了显著发展。这篇综述将总结我们目前对父亲在受孕时的代谢状态如何影响精子质量、受精后胚胎和胎儿发育以及后代健康的理解。
The association between maternal metabolic status at the time of conception and subsequent embryogenesis and offspring development has been studied in detail. However, less attention has been given to the significance of paternal nutrition and metabolism in directing offspring health. Despite this disparity, emerging evidence has begun to highlight an important connection between paternal metabolic well-being, semen quality, embryonic development and ultimately adult offspring health. This has established a new component within the Developmental Origins of Health and Disease hypothesis. Building on the decades of understanding and insight derived from the numerous models of maternal programming, attention is now becoming focused on defining the mechanisms underlying the links between paternal well-being, post-fertilisation development and offspring health. Understanding how the health and fitness of the father impact on semen quality is of fundamental importance for providing better information to intending fathers. Furthermore, assisted reproductive practices such as in vitro fertilisation rely on our ability to select the best quality sperm from a diverse and heterogeneous population. With considerable advances in sequencing capabilities, our understanding of the molecular and epigenetic composition of the sperm and seminal plasma, and their association with male metabolic health, has developed dramatically over recent years. This review will summarise our current understanding of how a father's metabolic status at the time of conception can affect sperm quality, post-fertilisation embryonic and fetal development and offspring health.