Enhanced penicillin production by oligosaccharides from batch cultures of Penicillium chrysogenum in stirred-tank reactors
Enhanced penicillin production by oligosaccharides from batch cultures of Penicillium chrysogenum in stirred-tank reactors
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DOI：
10.1016/s0378-1097(98)00326-7
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发表时间：
1998-09-01
影响因子：
2.1
通讯作者：
Keshavarz, T
中科院分区：
文献类型：
--
作者：
Ariyo, B;Tamerler, C;Keshavarz, T
将海藻酸盐和半乳甘露聚糖衍生的低聚糖添加到黄青霉的搅拌罐反应器培养物中，可提高青霉素G的产量。添加低聚甘露糖醛酸酯和低聚甘露糖酸盐块使青霉素G产量分别提高47%和49%。甘露寡糖的添加效果更明显，产量比对照提高69%。添加甘露寡糖后，低聚糖强化培养物的平均比生产率最大提高了55%。此外，青霉素生物合成中间体delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine.的积累模式在所有情况下都有所不同(C)1998年欧洲微生物学会联合会。爱思唯尔科学公司出版。版权所有。
Alginate and galactomannan-derived oligosaccharides enhanced the production of penicillin G when added to stirred tank reactor cultures of Penicillium chrysogenum. The addition of oligomannuronate and oligoguluronate blocks increased penicillin G yield by 47% and 49%, respectively. The effect of mannan oligosaccharides was found to be more pronounced with 69% higher yield than the control cultures. The maximum increase in the average specific productivity of the oligosaccharide augmented cultures was 55% after addition of mannan oligosaccharides. In addition, a difference was observed in all cases in the accumulation pattern of the intermediate of penicillin biosynthesis, delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine. (C) 1998 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.