Acoustic levitation: recent developments and emerging opportunities in biomaterials research

Acoustic levitation: recent developments and emerging opportunities in biomaterials research
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DOI:
10.1007/s00249-011-0767-3
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发表时间:
2012-04-01
影响因子:
2
通讯作者:
Byrn, Stephen R.
Byrn, Stephen R.
中科院分区:
生物学4区
文献类型:
--
作者:
Weber, Richard J. K.;Benmore, Chris J.;Byrn, Stephen R.

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无容器样品环境(悬浮)对于成核、过冷和玻璃化的研究以及新材料的合成(通常具有非平衡结构)非常有用。通过容器壁消除非本征形核,可以在高纯度条件下获得过冷和过饱和液体。声悬浮非常适合在室温左右研究液体,包括水溶液,有机物,软材料,聚合物和药物。本文综述了近年来声悬浮技术的发展及其在材料研究中的应用。给出了产生无定形药物材料的实验的实例。描述了在高能X射线束线上使用声悬浮器对过冷和过饱和液体进行实验的实施和结果。
Containerless sample environments (levitation) are useful for study of nucleation, supercooling, and vitrification and for synthesis of new materials, often with non-equilibrium structures. Elimination of extrinsic nucleation by container walls extends access to supercooled and supersaturated liquids under high-purity conditions. Acoustic levitation is well suited to the study of liquids including aqueous solutions, organics, soft materials, polymers, and pharmaceuticals at around room temperature. This article briefly reviews recent developments and applications of acoustic levitation in materials R&D. Examples of experiments yielding amorphous pharmaceutical materials are presented. The implementation and results of experiments on supercooled and supersaturated liquids using an acoustic levitator at a high-energy X-ray beamline are described.