Plasma Lipoprotein-associated Phospholipase A2 Is Inversely Correlated with Proprotein Convertase Subtilisin-kexin Type 9
Plasma Lipoprotein-associated Phospholipase A2 Is Inversely Correlated with Proprotein Convertase Subtilisin-kexin Type 9
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DOI：
10.1016/j.arcmed.2012.01.001
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发表时间：
2012-01-01
影响因子：
7.7
通讯作者：
Dullaart, Robin P. F.
中科院分区：
文献类型：
--
作者：
Constantinides, Alexander;Kappelle, Paul J. W. H.;Dullaart, Robin P. F.
背景与目标脂蛋白相关磷脂酶A（2）（Lp-PLA（2））是一种促动脉粥样硬化磷脂酶A（2），主要与低密度脂蛋白（LDL）颗粒复合。前蛋白转化酶枯草杆菌蛋白酶-kexin 9型（PCSK 9）通过刺激LDL受体降解提供LDL代谢的关键步骤。我们确定了血浆PCSK 9和Lp-PLA（2）质量之间的关系。本文采用比浊法测定了53例非糖尿病受试者（27例女性）的Lp-PLA（2）质量、PCSK_9和载脂蛋白（apo），并与体重指数（BMI）进行了比较
Background and Aims. Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a proatherogenic phospholipase A(2), which is predominantly complexed to low-density lipoprotein (LDL) particles. Proprotein convertase subtilisin-kexin type 9 (PCSK9) provides a key step in LDL metabolism by stimulating LDL receptor degradation. We determined relationships between plasma PCSK9 and Lp-PLA(2) mass.Methods. Lp-PLA(2) mass (turbidimetric immunoassay), PCSK9 (enzyme-linked immunosorbent assay) and (apo) lipoproteins were measured in 53 nondiabetic subjects (27 women) with body mass index