Numerical Simulations of Blood Flow in Artificial and Natural Hearts With Fluid-Structure Interaction
Numerical Simulations of Blood Flow in Artificial and Natural Hearts With Fluid-Structure Interaction
复制标题
DOI：
10.1111/j.1525-1594.2008.00644.x
复制
发表时间：
2008-11-01
影响因子：
2.4
通讯作者：
Bourgault, Yves
中科院分区：
文献类型：
--
作者：
Doyle, Matthew G.;Vergniaud, Jean-Baptiste;Bourgault, Yves
本文描述了两个正在进行的关于心血管系统流固相互作用的数值研究：一个理想的脉动心室辅助装置（VAD），由一个柔性隔膜分隔的两个流体室组成；犬心脏被动充盈时的血流和心壁运动。对VAD进行了仿真，并与前人的研究结果和我们自己的初步实验结果进行了比较。VAD模型中流场的详细测量和其他模拟正在进行中。使用理想的自然心脏模型和现实模型的初步模拟已经确定了当前数值方法在处理大的三维变形方面的局限性。正在进行的研究旨在扩大模拟的范围，以包括大变形，并将心脏壁的各向异性材料模型结合起来，以解释肌肉纤维。
This article describes two ongoing numerical studies of fluid-structure interaction in the cardiovascular system: an idealized pulsatile ventricular assist device (VAD), consisting of two fluid chambers separated by a flexible diaphragm; and blood flow and heart wall motion during passive filling of a canine heart. Simulations have been performed for the VAD and compared with the results of a previous study and to our own preliminary experimental results. Detailed measurements of the flow field in the VAD model and additional simulations are in progress. Preliminary simulations using both an idealized model of the natural heart as well as a realistic model have identified the limitations of the current numerical methods in dealing with large three-dimensional deformations. Ongoing research aims at extending the range of simulations to include large deformations and to incorporate an anisotropic material model for the heart wall to account for the muscle fibers.