NEUROFIBRILLARY TANGLES BUT NOT SENILE PLAQUES PARALLEL DURATION AND SEVERITY OF ALZHEIMERS-DISEASE
NEUROFIBRILLARY TANGLES BUT NOT SENILE PLAQUES PARALLEL DURATION AND SEVERITY OF ALZHEIMERS-DISEASE
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DOI：
10.1212/wnl.42.3.631
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发表时间：
1992-03-01
期刊：
影响因子：
9.9
通讯作者：
HYMAN, BT
中科院分区：
文献类型：
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作者：
ARRIAGADA, PV;GROWDON, JH;HYMAN, BT
我们研究了10名阿尔茨海默病患者的神经纤维缠结（NFT）和老年斑（SP）的积累，这些患者在生活中接受了检查。 我们在13个代表边缘系统、初级感觉和联合皮质的细胞结构区域以及皮质下神经递质特异性区域中计数了NFT和SP。 神经病理改变的程度与痴呆的严重程度进行了比较，通过Blessed痴呆量表和病程进行评估。 结果发现：（1）痴呆的严重程度与新皮层NFT的数量呈正相关，但与SP沉积的程度无关;（2）NFT的累积具有一致性，反映了单个细胞结构领域的等级脆弱性;（3）NFT在疾病过程的早期出现在内嗅皮层、海马结构的CA 1/下托区和杏仁核;（4）SP沉积的程度也与某些脑区对SP沉积的易感性有关，但SP的分布模式与NFT的分布模式不同。
We studied the accumulation of neurofibrillary tangles (NFTs) and senile plaques (SPs) in 10 Alzheimer's disease patients who had been examined during life. We counted NFTs and SPs in 13 cytoarchitectural regions representing limbic, primary sensory, and association cortices, and in subcortical neurotransmitter-specific areas. The degree of neuropathologic change was compared with the severity of dementia, as assessed by the Blessed Dementia Scale and duration of illness. We found that (1) the severity of dementia was positively related to the number of NFTs in neocortex, but not to the degree of SP deposition; (2) NFTs accumulate in a consistent pattern reflecting hierarchic vulnerability of individual cytoarchitectural fields; (3) NFTs appeared in the entorhinal cortex, CA1/subiculum field of the hippocampal formation, and the amygdala early in the disease process; and (4) the degree of SP deposition was also related to a hierarchic vulnerability of certain brain areas to accumulate SPs, but the pattern of SP distribution was different from that of NFT.