Underweight, overweight, and obesity as independent risk factors for hospitalization in adults and children from influenza and other respiratory viruses
Underweight, overweight, and obesity as independent risk factors for hospitalization in adults and children from influenza and other respiratory viruses
复制标题
体重不足、超重和肥胖是成人和儿童因流感和其他呼吸道病毒住院的独立风险因素
DOI：
10.1111/irv.12618
复制
发表时间：
2019-01-01
影响因子：
4.4
通讯作者：
Beigel, John H.
中科院分区：
文献类型：
--
作者：
Moser, Joe-Ann S.;Galindo-Fraga, Arturo;Beigel, John H.
背景2009年流感大流行期间所描述的肥胖与并发症风险之间的关系对于季节性流感和其他引起流感样疾病(ILI)的病毒原因的定义不明确。方法对墨西哥6家医院的ILI住院和门诊患者进行观察队列研究。对鼻咽拭子进行了流感和其他常见呼吸道病原体的检测。结果本研究共纳入4778名研究对象，资料完整。共有2053人(43.0%)有严重的ILI。流感阳性778例(16.3%)，其他呼吸道病原体阳性2 636例(55.2%)，未分离到呼吸道病毒1 364例(2 8.5%)。与体重正常的成年人相比，患有流感的成年人如果体重不足(OR：5.20)、肥胖(OR：3.18)或病态肥胖(OR：18.40)，更有可能住院治疗。与体重正常的成年人相比，患有H1N1流感的肥胖成年人住院的几率是H3N1和B型流感的6倍(肥胖OR：8.96比1.35，病态肥胖OR：35.13比5.58)。在患有冠状病毒、偏肺病毒、副流感和鼻病毒的成年人中，与正常体重的成年人相比，体重过轻(OR：4.07)和病态肥胖(OR：2.78)的参与者更有可能住院。所有原因的流感样疾病在体重不足或病态肥胖与住院之间也有类似但不那么明显的关联。结论体重不足或病态肥胖的成年参与者住院的风险增加，无论他们的病毒病原体状态如何。然而，患上流感会显著增加体重不足或病态肥胖的人住院的几率。
Background The relationship between obesity and risk of complications described during the 2009 influenza pandemic is poorly defined for seasonal influenza and other viral causes of influenza-like illness (ILI). Methods An observational cohort of hospitalized and outpatient participants with ILI was conducted in six hospitals in Mexico. Nasopharyngeal swabs were tested for influenza and other common respiratory pathogens. Results A total of 4778 participants were enrolled in this study and had complete data. A total of 2053 (43.0%) had severe ILI. Seven hundred and seventy-eight (16.3%) were positive for influenza, 2636 (55.2%) were positive for other viral respiratory pathogens, and 1364 (28.5%) had no respiratory virus isolated. Adults with influenza were more likely to be hospitalized if they were underweight (OR: 5.20), obese (OR: 3.18), or morbidly obese (OR: 18.40) compared to normal-weight adults. Obese adults with H1N1 had a sixfold increase in odds of hospitalization over H3N2 and B (obese OR: 8.96 vs 1.35, morbidly obese OR: 35.13 vs 5.58, respectively) compared to normal-weight adults. In adults with coronavirus, metapneumovirus, parainfluenza, and rhinovirus, participants that were underweight (OR: 4.07) and morbidly obese (OR: 2.78) were more likely to be hospitalized as compared to normal-weight adults. All-cause influenza-like illness had a similar but less pronounced association between underweight or morbidly obesity and hospitalization. Conclusions There is an increased risk of being hospitalized in adult participants that are underweight or morbidly obese, regardless of their viral pathogen status. Having influenza, however, significantly increases the odds of hospitalization in those who are underweight or morbidly obese.