High-energy breakfast based on whey protein reduces body weight, postprandial glycemia and HbA1c in Type 2 diabetes
High-energy breakfast based on whey protein reduces body weight, postprandial glycemia and HbA1c in Type 2 diabetes
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DOI：
10.1016/j.jnutbio.2017.07.005
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发表时间：
2017-11-01
影响因子：
5.6
通讯作者：
Froy, Oren
中科院分区：
文献类型：
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作者：
Jakubowicz, Daniela;Wainstein, Julio;Froy, Oren
急性研究表明，早餐添加乳清蛋白通过增加肠促胰岛素和胰岛素分泌具有降血糖作用。然而，这是否对 2 型糖尿病有长期影响尚不清楚。 56 名年龄 58.9 +/- 4.5 岁、BMI 32.1 +/- 0.9 kg/m(2) 和 HbA(1c) 7.8 +/- 0.1% (61.6 +/- 0.79 mmol/mol) 的 2 型糖尿病参与者随机接受 3 种等热量饮食之一，午餐和晚餐相似，但早餐不同：1) 42 g 总蛋白，28 g 乳清 (WBdiet,n=19);2)42 g 各种蛋白质来源 (PBdiet,n=19);或 3) 高碳水化合物早餐，17 克各种来源的蛋白质（CBdiet，n=18）。 12周后检查体重和HbA(1c)。所有参与者都接受了三项全天膳食挑战，包括餐后血糖、胰岛素、C 肽、完整胰高血糖素样肽 1 (iGLP-1)、生长素释放肽以及饥饿和饱腹感评分。与 CBdiet 相比，PBdiet 的总体餐后 AUC（葡萄糖）降低了 12%，WBdiet 降低了 19%（P
Acute studies show that addition of whey protein at breakfast has a glucose-lowering effect through increased incretin and insulin secretion. However, whether this is a long-term effect in Type 2 diabetes is unknown. Fifty-six Type 2 diabetes participants aged 58.9 +/- 4.5 years, BMI 32.1 +/- 0.9 kg/m(2) and HbA(1c) 7.8 +/- 0.1% (61.6 +/- 0.79 mmol/mol) were randomized to one of 3 isocaloric diets with similar lunch and dinner, but different breakfast: 1) 42 g total protein, 28 g whey (WBdiet,n=19);2)42 g various protein sources (PBdiet,n=19); or 3) high-carbohydrate breakfast, 17 g protein from various sources (CBdiet, n=18). Body weight and HbA(1c) were examined after 12 weeks. All participants underwent three all-day meal challenges for postprandial glycemia, insulin, C-peptide, intact glucagon-like peptide 1 (iGLP-1), ghrelin and hunger and satiety scores. Overall postprandial AUC(glucose) was reduced by 12% in PBdiet and by 19% in WBdiet, compared with CBdiet (P