Stability of pediatric liquid dosage forms of ethacrynic acid, indomethacin, methyldopate hydrochloride, prednisone and spironolactone.
Stability of pediatric liquid dosage forms of ethacrynic acid, indomethacin, methyldopate hydrochloride, prednisone and spironolactone.
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依他尼酸、吲哚美辛、盐酸甲酯、泼尼松和螺内酯的儿科液体剂型的稳定性。
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
A. Ghanekar
中科院分区：
文献类型：
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作者：
V. D. Das Gupta;C. W. Gibbs;A. Ghanekar
研究了依他尼酸（1 mg/ml）、吲哚美辛（2 mg/ml）、盐酸甲基多巴（25 mg/ml）、泼尼松（0.5 mg/ml）和螺内酯（2 mg/ml）的液体剂型的稳定性，这些剂型通常是临时配制的。五种药物中的每一种的一种或两种液体剂型用纯药物或单独使用含水山梨醇或简单糖浆或与10%（v/v）酒精水溶液的商业剂型的粉末制备。将该剂型在琥珀色瓶中于24 ℃下储存21-224天，并通过各种方法进行测定。研究的所有溶液均稳定至少84天。如果溶液保留90%的药物浓度，则认为溶液稳定。除泼尼松溶液外，所有溶液均稳定至少164天;然而，由纯药物制备的盐酸甲基多巴溶液在98天后变色。所研究的液体剂型具有有限的稳定性，但当需要这些药物的临时口服溶液时，药剂师可以使用。
The stability of liquid dosage forms of ethacrynic acid (1 mg/ml), indomethacin (2 mg/ml), methyldopate hydrochloride (25 mg/ml), prednisone (0.5 mg/ml) and spironolactone (2 mg/ml), which often are compounded extemporaneously, was studied. One or two liquid dosage forms of each of the five drugs was prepared with the pure drug or the powder from a commercial dosage form using aqueous sorbitol or simple syrup alone or with a 10% (v/v) solution of alcohol in water. The dosage forms were stored at 24 C in amber-colored bottles for 21-224 days and assayed by various methods. All solutions studied were stable for at least 84 days. A solution was considered stable if it retained 90% of its drug concentration. Except for the prednisone solution, all solutions were stable for at least 164 days; however, the solution of methyldopate hydrochloride prepared from the pure drug became discolored after 98 days. The liquid dosage forms studied have limited stability but can be used by the pharmacist when extemporaneous oral solutions of these drugs are needed.