Aberrant localization of importin α1 in hippocampal neurons in Alzheimer disease
Aberrant localization of importin α1 in hippocampal neurons in Alzheimer disease
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DOI：
10.1016/j.brainres.2006.09.084
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发表时间：
2006-12-08
期刊：
影响因子：
2.9
通讯作者：
Zhu, Xiongwei
中科院分区：
文献类型：
--
作者：
Lee, Hyoung-gon;Ueda, Masumi;Zhu, Xiongwei
由于许多核蛋白异位定位于阿尔茨海默病(AD)易损神经元的胞浆中，我们推测AD可能存在胞浆-核转运机制的故障。为了支持这一观点，我们发现，在AD患者脆弱的海马神经元的平野小体中，作为细胞质-核运输的重要组成部分，Importinα1异常积聚。这些数据表明，在AD患者中，Importin介导的胞质-核转运存在障碍。(C)2006爱思唯尔B.V.保留所有权利。
Since many nuclear proteins are ectopically localized in the cytoplasm in the vulnerable neurons in Alzheimer disease (AD), we speculated that there is failure of the cytoplasmic-nuclear transport machinery in AD. In support of this notion, we found that importin alpha 1, an essential component of cytoplasmic-nuclear transport, is abnormally accumulated in Hirano bodies in vulnerable hippocampal neurons in AD. These data suggest a hindrance in importin-mediated cytoplasmic-nuclear transport in AD. (c) 2006 Elsevier B.V. All rights reserved.