The role of biomechanics in the initiation and progression of OA of the knee
The role of biomechanics in the initiation and progression of OA of the knee
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DOI：
10.1016/j.berh.2009.08.008
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发表时间：
2010-02-01
影响因子：
5.2
通讯作者：
Englund, Martin
中科院分区：
文献类型：
--
作者：
Englund, Martin
膝关节是骨关节炎（OA）最常见的关节之一，通常在中年甚至更早出现临床表现。越来越多的证据表明，膝关节OA的进展通常是由生物力学力驱动的，组织对这些力的病理反应导致关节结构恶化、膝关节症状和功能下降。众所周知的生物力学危险因素包括关节错位和半月板撕裂。膝关节损伤后骨性关节炎的高风险表明生物力学因素在易感个体的偶发疾病中也起着关键作用。然而，我们对早期疾病发展的生物力学机制及其重要性排序的了解是有限的。部分问题在于我们目前缺乏对早期OA的理解，它何时开始以及如何定义它。2009爱思唯尔有限公司版权所有。
The knee is one of the most common joints affected by osteoarthritis (OA), frequently with clinical presentation by middle age or even earlier. Accumulating evidence supports that knee OA progression is often driven by biomechanical forces, and the pathological response of tissues to such forces leads to structural joint deterioration, knee symptoms and reduced function. Well-known biomechanical risk factors for progression include joint malalignment and meniscal tear. The high risk of OA after knee injury demonstrates the critical role of biomechanical factors also in incident disease in susceptible individuals. However, our knowledge of the contributing biomechanical mechanisms in the development of early disease and their order of significance is limited. Part of the problem is our current lack of understanding of early-stage OA, when it starts and how to define it. (C) 2009 Elsevier Ltd. All rights reserved.