Amygdala-hippocampal dynamics during salient information processing.
Amygdala-hippocampal dynamics during salient information processing.
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DOI：
10.1038/ncomms14413
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发表时间：
2017-02-08
影响因子：
16.6
通讯作者：
Lin JJ
中科院分区：
文献类型：
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作者：
Zheng J;Anderson KL;Leal SL;Shestyuk A;Gulsen G;Mnatsakanyan L;Vadera S;Hsu FP;Yassa MA;Knight RT;Lin JJ
识别动机显著信息对于指导行为至关重要。杏仁核和海马被认为支持这种操作，但这种相互作用的回路水平机制尚不清楚。我们使用人类癫痫患者杏仁核和海马体的直接记录来检查恐惧面孔与中性景观处理过程中的振荡活动。我们报告高伽玛（70-180赫兹）激活恐惧的面孔与更早的刺激诱发发作杏仁核相比，海马。与中性景观刺激相比，关注恐惧的面孔增强了杏仁核和海马体之间的低频耦合。杏仁核和海马之间的相互作用主要是单向的，杏仁核中的θ/α振荡调节海马γ活性。格兰杰预测、相位斜率指数和相位滞后分析证实了这种定向耦合。这些结果表明，在人类处理情绪突出的事件从事杏仁核-海马网络，杏仁核影响海马动力学在恐惧处理。杏仁核和海马体参与处理动机显著的刺激，但相互作用的精确回路动力学尚不清楚。在这里，作者表明，在人类对恐惧面孔的反应中，杏仁核中的θ/α振荡调节海马活动动力学。
Recognizing motivationally salient information is critical to guiding behaviour. The amygdala and hippocampus are thought to support this operation, but the circuit-level mechanism of this interaction is unclear. We used direct recordings in the amygdala and hippocampus from human epilepsy patients to examine oscillatory activity during processing of fearful faces compared with neutral landscapes. We report high gamma (70–180 Hz) activation for fearful faces with earlier stimulus evoked onset in the amygdala compared with the hippocampus. Attending to fearful faces compared with neutral landscape stimuli enhances low-frequency coupling between the amygdala and the hippocampus. The interaction between the amygdala and hippocampus is largely unidirectional, with theta/alpha oscillations in the amygdala modulating hippocampal gamma activity. Granger prediction, phase slope index and phase lag analysis corroborate this directional coupling. These results demonstrate that processing emotionally salient events in humans engages an amygdala-hippocampal network, with the amygdala influencing hippocampal dynamics during fear processing. Amygdala and hippocampus are involved in processing motivationally salient stimuli but the precise circuit dynamics of the interaction is not understood. Here the authors show that in response to fearful faces in humans, theta/alpha oscillations in the amygdala modulate hippocampal activity dynamics.