Physiological basis of tingling paresthesia evoked by hydroxy-alpha-sanshool.
Physiological basis of tingling paresthesia evoked by hydroxy-alpha-sanshool.
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DOI：
10.1523/jneurosci.4666-09.2010
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发表时间：
2010-03-24
期刊：
影响因子：
--
通讯作者：
Stucky CL
中科院分区：
文献类型：
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作者：
Lennertz RC;Tsunozaki M;Bautista DM;Stucky CL
羟基-α-山椒醇是花椒植物家族中的活性成分，通过激活一部分躯体感觉神经元诱导强烈的刺痛感觉异常。然而，山椒素敏感神经元的亚型和生理功能尚不清楚。在这里，我们使用离体皮肤神经制备来检查皮肤神经元的感觉末梢对羟基-α-山椒素的反应的模式和强度。我们发现，山椒素几乎可以激发所有的D毛传入神经，这是皮肤中超敏感的光触觉受体的一个独特子集，并以Aβ和C纤维神经传入神经的新群体为目标。因此，山椒提供了一种新的药理学工具，用于区分皮肤机械感受器的功能亚型。鉴别山椒素敏感纤维是鉴别伴随周围神经病变和损伤的麻刺感觉异常的细胞和分子机制的重要第一步。
Hydroxy-α-sanshool, the active ingredient in plants of the prickly ash plant family, induces robust tingling paresthesia by activating a subset of somatosensory neurons. However, the subtypes and physiological function of sanshool-sensitive neurons remain unknown. Here we use the ex vivo skin-nerve preparation to examine the pattern and intensity with which the sensory terminals of cutaneous neurons respond to hydroxy-α-sanshool. We found that sanshool excites virtually all D-hair afferents, a distinct subset of ultra-sensitive light touch receptors in the skin, and targets novel populations of Aβ and C-fiber nerve afferents. Thus, sanshool provides a novel pharmacological tool for discriminating functional subtypes of cutaneous mechanoreceptors. The identification of sanshool-sensitive fibers represents an essential first step in identifying the cellular and molecular mechanisms underlying tingling paresthesia that accompanies peripheral neuropathy and injury.