Seaweed intake and risk of cardiovascular disease: the Japan Public Health Center-based Prospective (JPHC) Study
Seaweed intake and risk of cardiovascular disease: the Japan Public Health Center-based Prospective (JPHC) Study
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DOI：
10.1093/ajcn/nqz231
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发表时间：
2019-12-01
影响因子：
7.1
通讯作者：
Tsugane, Shoichiro
中科院分区：
文献类型：
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作者：
Murai, Utako;Yamagishi, Kazumasa;Tsugane, Shoichiro
背景：海藻中的矿物质、维生素、可溶性膳食纤维和黄酮类化合物具有预防心血管疾病的作用。然而，海藻摄入量与心血管疾病风险之间的关联尚未确定。 目的：我们在日本研究人群中检查了海藻的膳食摄入量及其对中风和缺血性心脏病风险的影响。方法：我们调查了来自 2 个大队列的 40,707 名男性和 45,406 名女性（年龄范围：40-69 岁）。海藻摄入量通过 FFQ 确定基线（1990-1994 年）。中风和缺血性心脏病的发病率一直持续到 2009 年底（第一组）或 2012 年（第二组）为止。按区域分层并调整心血管疾病风险和饮食因素后，使用 Cox 比例风险模型估计性别特异性心血管疾病 HR (95% CI)。结果：在 1,493,232 人年的随访期间，有 4777 例中风（2863 例缺血性中风、1361 例脑实质出血和 531 例蛛网膜下腔出血）和 1204 例缺血性中风发现了心脏病病例。在男性中，与几乎不食用海藻相比，几乎每天食用海藻的缺血性心脏病患者具有显着的多变量 HR（95% CI）[0.76 (0.58, 0.99)； P-趋势 = 0.04] 和总心血管疾病 [0.88 (0.78, 1.00)； P-趋势 = 0.08]。在女性中，缺血性心脏病的负相关系数为 0.56 (0.36, 0.85; P-趋势 = 0.006)，总体心血管疾病的负相关系数为 0.89 (0.76, 1.05; P-趋势 = 0.10)。在男性或女性中，海藻摄入量与总中风或中风类型的风险之间没有观察到显着关联。结论：海藻摄入量与缺血性心脏病的风险呈负相关。
Background: The minerals, vitamins, soluble dietary fibers, and flavonoids of seaweed are protective for preventing cardiovascular diseases. However, the association between seaweed intake and risk of cardiovascular disease has not been established.Objectives: We examined the dietary intake of seaweed and its impact upon stroke and ischemic heart disease risk among a Japanese study population.Methods: We surveyed 40,707 men and 45,406 women from 2 large cohorts (age range: 40-69 y). Seaweed intake was determined by FFQ at baseline (1990-1994). Incidences of stroke and ischemic heart disease were ascertained until the end of 2009 (Cohort I) or 2012 (Cohort II). Sex-specific cardiovascular disease HRs (95% CIs) were estimated using Cox proportional hazard models after stratification by area and adjustment for cardiovascular disease risk and dietary factors.Results: During 1,493,232 person-years of follow-up, 4777 strokes (2863 ischemic stroke, 1361 intraparenchymal hemorrhages, and 531 subarachnoid hemorrhages) and 1204 ischemic heart disease cases were identified. Among men, significant multivariable HRs (95% CIs) for almost daily consumption compared with almost no consumption of seaweed were seen in ischemic heart disease [0.76 (0.58, 0.99); P-trend = 0.04] and total cardiovascular diseases [0.88 (0.78, 1.00); P-trend = 0.08]. Among women, such inverse associations were 0.56 (0.36, 0.85; P-trend = 0.006) for ischemic heart disease and 0.89 (0.76, 1.05; P-trend = 0.10) for total cardiovascular diseases. No significant associations were observed between seaweed intake and risk of total stroke or stroke types among either men or women.Conclusions: Seaweed intake was inversely associated with risk of ischemic heart disease.