Imaging of metabolites by MALDI mass spectrometry.
Imaging of metabolites by MALDI mass spectrometry.
复制标题
通过 MALDI 质谱法对代谢物进行成像。
作者：
N. Zaima;T. Hayasaka;Naoko Goto;M. Setou
小动物体内内源性分子的可视化是研究特定分子定位的重要手段。传统的成像技术不适合内源性分子的同时可视化。我们最近开发了一种新的成像方法-成像质谱（IMS），使用基质辅助激光解吸/电离四极离子阱飞行时间（MALDI-QIT-TOF）。在本研究中，我们利用IMS利用MALDI-QIT-TOF对米卡卡（Oryzias latipes）切片的代谢物进行可视化，并确定了包括脂质的代谢物的空间分布。
Visualization of endogenous molecules in small experimental animals is very important in order to investigate the localization of specific molecules. Conventional imaging techniques are not suitable for simultaneous visualization of endogenous molecules. We recently developed a new imaging method-imaging mass spectrometry (IMS) using matrix-assisted laser desorption/ionization quadrupole ion trap time-of-flight (MALDI-QIT-TOF). In this study, we applied IMS using MALDI-QIT-TOF to visualize the metabolites in medaka (Oryzias latipes) sections and determined the spatial distribution of metabolites including lipids.
影响因子：
7.4
作者：
Khatib-Shahidi, Sheerin;Andersson, Malin;Caprioli, Richard M.
通讯作者：
Caprioli, Richard M.
影响因子：
2.3
作者：
Reyzer, ML;Hsieh, YS;Caprioli, RM
通讯作者：
Caprioli, RM