Cytotoxic T lymphocyte lines (CTLL) against a human minor alloantigen.
Cytotoxic T lymphocyte lines (CTLL) against a human minor alloantigen.
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针对人类次要同种抗原的细胞毒性 T 淋巴细胞系 (CTLL)。
DOI：
10.1007/bf00345909
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发表时间：
1982
期刊：
影响因子：
3.2
通讯作者：
Pierson,GR
中科院分区：
文献类型：
--
作者：
Zier,KS;Elkins,WL;Pierson,GR
细胞毒性T细胞系产生后，在体外培养的淋巴细胞从一个病人患有再生障碍性贫血连同他的HLA相同的兄弟，重复输血供体。这些细胞毒性细胞检测到的决定簇家族内的分离模式强烈表明检测到了次要同种异体抗原。对一组无关个体的效应子测试表明，它与HLA-B7相关性最好，这在患者和他的同胞供体中都很常见。
Cytotoxic T-cell lines were generated following in vitro culture of lymphocytes from a patient suffering from aplastic anemia together with those of his HLA-identical brother, a repeated transfusion donor. The segregation pattern within the family of the determinant(s) detected by these cytotoxic cells strongly suggested that a minor alloantigen(s) was being detected. Testing of the effectors on a panel of unrelated individuals indicated that it was best seen in association with HLA-B7, which was common to both the patient and his sibling donor.