DTI Indicators of White Matter Injury are Correlated with Multimodal EEG-based Biomarker in Slow Recovering, Concussed Collegiate Athletes.
DTI Indicators of White Matter Injury are Correlated with Multimodal EEG-based Biomarker in Slow Recovering, Concussed Collegiate Athletes.
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在恢复缓慢、脑震荡的大学运动员中，白质损伤的 DTI 指标与基于多模式脑电图的生物标志物相关。
DOI：
10.1089/neu.2018.6365
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发表时间：
2020
影响因子：
4.2
通讯作者：
H. Levin
中科院分区：
文献类型：
--
作者：
E. Wilde;N. Goodrich;A. L. Ware;Brian A. Taylor;Brian D. Biekman;J. Hunter;R. Newman;Samantha E. Scarneo;D. Casa;H. Levin
运动相关脑震荡尚无有效的、客观的诊断或预后生物标志物，这阻碍了对脑震荡运动员的循证治疗。虽然定量电生理学和扩散张量成像是为脑震荡提供客观生物标志物的有前途的技术，但它们在脑震荡运动员中的关联程度尚未得到系统的研究。这项研究检查了弥散指标是否区分脑震荡恢复时间延长的运动员(n=18)和非脑震荡运动员(n=13)，以及观察到的弥散变化是否与电生理有关。31名大学生运动员完成了电生理学、神经认知和磁共振成像。白质弥散率在多条白质束上的组间差异有统计学意义，这些白质束包括穹隆体束、扣带束、丘脑放射束、额枕下束、纵束下束和钩束束，但经多次比较校正后无差异。增强的脑功能指数结合了电生理学和神经认知数据，与脑震荡运动员的扩散改变显著相关。这些初步发现表明，脑震荡运动员与非脑震荡运动员弥散指标的绝对偏差可能具有临床实用价值。结果还表明，增强的脑功能指数可能对运动相关脑震荡的早期变化敏感。
There are no validated, objective diagnostic or prognostic biomarkers for sports-related concussion, which hinders evidence-based treatment for concussed athletes. While quantitative electrophysiology and diffusion tensor imaging are promising technologies for providing objective biomarkers for concussion, the degree to which they are related has not been systematically investigated in concussed athletes. This study examined whether diffusion metrics differentiated concussed athletes with prolonged recovery (n = 18) from nonconccused athletes (n = 13), and whether observed diffusion alterations related to electrophysiology. Collegiate athletes (N = 31) completed electrophysiology, neurocognitive, and magnetic resonance imaging. White matter diffusivity differed between the groups in multiple white matter tracts, including the corpus callosum, cingulum bundle, thalamic radiations, and the inferior fronto-occipital, inferior longitudinal, and uncinate fasciculi, but not after correction for multiple comparisons. The enhanced brain function index, a measure that combines electrophysiology and neurocognitive data, significantly correlated with altered diffusion in the concussed athletes. These preliminary findings suggest that the absolute deviation of diffusion metrics in concussed versus nonconcussed athletes may have clinically utility. Results also suggested that the enhanced brain function index may be sensitive to early changes from sports-related concussion.
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影响因子：
4.2
作者：
Davenport, Elizabeth M.;Whitlow, Christopher T.;Maldjian, Joseph A.
通讯作者：
Maldjian, Joseph A.
影响因子：
4.2
作者：
Davenport, Elizabeth M.;Apkarian, Kalyna;Maldjian, Joseph A.
通讯作者：
Maldjian, Joseph A.
轻度创伤性脑损伤神经影像研究的骨科受伤与未受伤比较组。
影响因子：
4.2
作者：
Wilde,ElisabethA;Ware,AshleyL;Li,Xiaoqi;Wu,TrevorC;McCauley,StephenR;Barnes,Amanda;Newsome,MaryR;Biekman,BrianD;Hunter,JillV;Chu,ZiliD;Levin,HarveyS
通讯作者：
Levin,HarveyS
影响因子：
2.5
作者：
Bazarian, Jeffrey J.;Zhu, Tong;Blyth, Brian;Borrino, Allyson;Zhong, Jianhui
通讯作者：
Zhong, Jianhui