Impact of nocturnal heart rate variability on cerebral small-vessel disease progression: a longitudinal study in community-dwelling elderly Japanese
Impact of nocturnal heart rate variability on cerebral small-vessel disease progression: a longitudinal study in community-dwelling elderly Japanese
复制标题
DOI：
10.1038/hr.2015.38
复制
发表时间：
2015-08-01
影响因子：
5.4
通讯作者：
Kato, Takeo
中科院分区：
文献类型：
--
作者：
Yamaguchi, Yoshitaka;Wada, Manabu;Kato, Takeo
最近的证据表明，动态心率（HR）对心血管事件和死亡率的影响。我们的目的是确定动态心率是否与社区老年人脑小血管疾病（SVD）或认知功能下降的进展有关。对190名社区老年人进行了动态血压监测（ABPM）、脑磁共振成像（MRI）和认知测试，4年后重复MRI和认知测试。通过s.d.定量ABPM中的HR变异性。（标准差）和连续差异的均方根（RMSSD），并研究HR变异性与SVD/认知功能下降进展之间的关系。我们还评估了夜间心率变异性和夜间心率下降的相关性。有SVD进展者夜间RMSSD显著高于无SVD进展者（P
Recent evidence has shown an effect of ambulatory heart rate (HR) on cardiovascular events and mortality. Our objective was to determine whether ambulatory HR was related to the progression of cerebral small-vessel disease (SVD) or cognitive decline in community-dwelling elderly people. A cohort of 190 community-dwelling elderly people underwent an ambulatory blood pressure monitoring (ABPM), brain magnetic resonance imaging (MRI) and cognitive testing at baseline, with MRI and cognitive tests repeated 4 years later. HR variability in ABPM was quantified by the s.d. (s.d. and the root mean square of successive differences (RMSSD), and the relationship between HR variability and the progression of SVD/cognitive decline was investigated. We also assessed the association of nighttime HR variability and nocturnal HR dipping. The nighttime RMSSD of participants with the progression of SVD was significantly higher than that of those without progression of SVD (P