The emerging face of primary cilia.
The emerging face of primary cilia.
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DOI：
10.1002/dvg.20728
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发表时间：
2011-04
期刊：
影响因子：
--
通讯作者：
Brugmann SA
中科院分区：
文献类型：
--
作者：
Zaghloul NA;Brugmann SA
Primary cilia are microtubule-based organelles that serve as hubs for the transduction of various developmental signaling pathways including Hedgehog, Wnt, FGF and PDGF. Ciliary dysfunction contributes to a range of disorders, collectively known as the ciliopathies. Recently, interest has grown in these syndromes, particularly among craniofacial biologists, as many known and putative ciliopathies have severe craniofacial defects. Herein we discuss the current understanding of ciliary biology and craniofacial development in an attempt to gain insight into the molecular etiology for craniofacial ciliopathies, and uncover a characteristic ciliopathic craniofacial gestalt.
