Altered Temporal Variance and Neural Synchronization of Spontaneous Brain Activity in Anesthesia
Altered Temporal Variance and Neural Synchronization of Spontaneous Brain Activity in Anesthesia
复制标题
麻醉中自发脑活动的时间方差和神经同步改变
DOI：
10.1002/hbm.22556
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发表时间：
2014-11-01
影响因子：
4.8
通讯作者：
Northoff, Georg
中科院分区：
文献类型：
--
作者：
Huang, Zirui;Wang, Zhiyao;Northoff, Georg
最近在细胞和区域水平上的研究已经指出了神经同步和神经活动的时间变异的多方面重要性。例如，我们已经证明，在植物人状态（VS）的患者中，神经同步和时间变异会发生改变。然而，这一发现留下了一个悬而未决的问题，即这些异常是VS特有的，还是更普遍地与意识缺失有关。本研究的目的是探讨麻醉诱导无意识状态下区域间和区域内神经同步的变化以及静息状态活动的时间变异。采用受试者内设计，我们比较了同一受试者在清醒和麻醉状态下的功能磁共振成像（fMRI）静息状态活动。重复以往的研究，我们观察到在麻醉状态下，默认模式网络（DMN）和丘脑皮质网络的功能连通性降低。重要的是，通过区域均匀性（ReHo）测量的区域内同步和通过标准偏差（SD）测量的时间方差在麻醉状态下，特别是皮质中线区域显著降低，而在皮质外侧区域增加。我们进一步发现丘脑中SD的频率依赖性显著，在麻醉状态下，在Slow - 5 （0.01-0.027 Hz）中显示出异常高的SD。我们的结果首次显示了麻醉下静息状态活动的时间变化。结合我们在植物人状态下的发现，这些发现表明时间变异、神经同步和意识之间存在密切关系。中国生物医学工程学报（英文版），2014。©2014 Wiley期刊公司
Recent studies at the cellular and regional levels have pointed out the multifaceted importance of neural synchronization and temporal variance of neural activity. For example, neural synchronization and temporal variance has been shown by us to be altered in patients in the vegetative state (VS). This finding nonetheless leaves open the question of whether these abnormalities are specific to VS or rather more generally related to the absence of consciousness. The aim of our study was to investigate the changes of inter‐ and intra‐regional neural synchronization and temporal variance of resting state activity in anesthetic‐induced unconsciousness state. Applying an intra‐subject design, we compared resting state activity in functional magnetic resonance imaging (fMRI) between awake versus anesthetized states in the same subjects. Replicating previous studies, we observed reduced functional connectivity within the default mode network (DMN) and thalamocortical network in the anesthetized state. Importantly, intra‐regional synchronization as measured by regional homogeneity (ReHo) and temporal variance as measured by standard deviation (SD) of the BOLD signal were significantly reduced in especially the cortical midline regions, while increased in the lateral cortical areas in the anesthetized state. We further found significant frequency‐dependent effects of SD in the thalamus, which showed abnormally high SD in Slow‐5 (0.01–0.027 Hz) in the anesthetized state. Our results show for the first time of altered temporal variance of resting state activity in anesthesia. Combined with our findings in the vegetative state, these findings suggest a close relationship between temporal variance, neural synchronization and consciousness. Hum Brain Mapp 35:5368–5378, 2014. © 2014 Wiley Periodicals, Inc.