The atopic march: current insights into skin barrier dysfunction and epithelial cell-derived cytokines.
The atopic march: current insights into skin barrier dysfunction and epithelial cell-derived cytokines.
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DOI：
10.1111/imr.12546
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发表时间：
2017-07
影响因子：
8.7
通讯作者：
Ziegler SF
中科院分区：
文献类型：
--
作者：
Han H;Roan F;Ziegler SF
特应性皮炎通常先于其他特应性疾病的发展。特应性进行曲描述了特应性疾病自然史中的这种时间关系。尽管这种关系背后的病理生理机制尚不清楚，但流行病学和遗传学数据表明，皮肤可能是对过敏原致敏的重要途径。动物模型已经开始阐明皮肤屏障缺陷如何导致全身过敏原致敏。新出现的数据表明，上皮细胞来源的细胞因子，如胸腺基质淋巴生成素（TSLP）、IL-33和IL-25可能推动特应性皮炎向哮喘和食物过敏的进展。本文综述了目前关于皮肤屏障缺陷和上皮细胞源性细胞因子在过敏性炎症和特应性进展的开始和维持中的作用的概念。
Atopic dermatitis often precedes the development of other atopic diseases. The atopic march describes this temporal relationship in the natural history of atopic diseases. Although the pathophysiological mechanisms that underlie this relationship are poorly understood, epidemiological and genetic data have suggested that the skin might be an important route of sensitization to allergens. Animal models have begun to elucidate how skin barrier defects can lead to systemic allergen sensitization. Emerging data now suggest that epithelial cell-derived cytokines such as thymic stromal lymphopoietin (TSLP), IL-33, and IL-25 may drive the progression from atopic dermatitis to asthma and food allergy. This review focuses on current concepts of the role of skin barrier defects and epithelial cell-derived cytokines in the initiation and maintenance of allergic inflammation and the atopic march.