Cognitive impairment and hippocampal atrophy in chronic kidney disease
Cognitive impairment and hippocampal atrophy in chronic kidney disease
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DOI：
10.1111/ane.12753
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发表时间：
2017-11-01
影响因子：
3.5
通讯作者：
Fuh, J. -L.
中科院分区：
文献类型：
--
作者：
Chang, C. -Y.;Lin, C. -C.;Fuh, J. -L.
背景：认知障碍是众所周知的慢性肾脏疾病（CKD）患者。CKD患者脑结构与认知表现之间的关系仍在研究中。该研究旨在定量评估CKD患者大脑结构与认知表现之间的关系。方法：我们从一家三级医疗中心招募了39名CKD患者和39名年龄和性别匹配的对照组。所有参与者都进行了3-T MRI扫描、神经心理评估和肾功能测试。使用FreeSurfer软件进行成像处理和分析，包括测量皮质厚度、灰质（GM）和白质体积。结果：与对照组（73.1 +/- 7.5岁）相比，CKD患者（76.4 +/- 8.4岁）在小精神状态检查和前指跨距测试中的得分显著低于对照组（P < 0.05）
Background: Cognition impairment is well known in patients with chronic kidney disease (CKD). The relationship between brain structure and cognitive performance in CKD patients is still under investigation. The study aimed to quantitatively assess the relationship between brain structure and cognitive performance in patients with CKD.Methods: We recruited 39 patients with CKD and 39 age- and sex-matched control participants from a tertiary medical center. All participants underwent 3-T MRI scan neuropsychological assessments, and renal function tests. FreeSurfer software was used for imaging processing and analysis, including measurement of cortical thickness and gray matter (GM) and white matter volumes.Results: Compared with control subjects (73.1 +/- 7.5 years old), patients with CKD (76.4 +/- 8.4 years old) had significantly lower scores on the Mini-Mental State Examination, and forward digit span test (P