Elevated vascular reactivity in the timolol-treated spontaneously hypertensive rat.
Elevated vascular reactivity in the timolol-treated spontaneously hypertensive rat.
复制标题
噻吗洛尔治疗的自发性高血压大鼠血管反应性升高。
DOI：
10.1139/y78-174
复制
发表时间：
1978
影响因子：
2.1
通讯作者：
C. Triggle
中科院分区：
文献类型：
--
作者：
M. Goldberg;C. Triggle
Spontaneously hypertensive rats (SHR) treated in utero with a low dose, and from weaning with 6 mg/kg per day of oral timolol, a noncardioselective beta-adrenergic blocker, did not develop hypertension. Isolated aortic rings from these animals showed increased reactivity to raised extracellular K+, when compared with tissues from timolol-treated Kyoto-Wistar (WKY) control rats. The normotensive SHR aorta also showed significant responsiveness to H+ and to high Ca2+ concentrations without previously depolarizing the tissue with high K+. These observations suggest that the increased reactivity seen in vascular smooth muscle from this animal does not develop secondary to elevated peripheral resistance and subsequent hypertrophy, and that the initiation of hypertension in this animal may be related to a membrane defect and (or) cellular defect which results in a facilitation of Ca2+ availability for the contractile proteins of the SHR vascular smooth muscle cell.
