Association between number of dissected lymph nodes and survival in stage IA non-small cell lung cancer: a propensity score matching analysis.
Association between number of dissected lymph nodes and survival in stage IA non-small cell lung cancer: a propensity score matching analysis.
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DOI：
10.1186/s12957-020-02090-5
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发表时间：
2020-12-07
影响因子：
3.2
通讯作者：
Ma GW
中科院分区：
文献类型：
--
作者：
Wu LL;Lai JJ;Liu X;Huang YY;Lin P;Long H;Zhang LJ;Ma GW
对于肿瘤大小≤2 cm的IA期非小细胞肺癌（NSCLC）患者，不同手术方式切除淋巴结（nln）数量对预后的意义尚不清楚。目的探讨不同肺手术治疗肿瘤大小≤2cm的IA期NSCLC患者nln与肿瘤特异性生存期（CSS）和总生存期（OS）的关系。我们回顾性地从监测、流行病学和最终结果数据库中招募了7293例患者。采用nln中位数法将患者分为两组：nln≤5的A组和nln≤50的B组。采用倾向得分匹配（PSM）来减少选择偏差。采用Kaplan-Meier分析和Cox回归分析来确定nln与生存结果之间的关系。未配对组和配对组的生存率均高于A组（P < 0.05）。多变量分析显示，nln显著影响未匹配队列和匹配队列中符合条件病例的CSS和OS。此外，我们发现nln是楔形切除术、节段性切除术或肺叶切除术患者发生OS的保护性预后预测因子。在肿瘤大小≤2cm的非小细胞肺癌患者中，NLNs是一个保护预后的因素。我们证明，在楔形切除术、节段性切除术或肺叶切除术队列中，bbb50 NLNs患者表现出明显更好的OS。
For patients with stage IA non-small cell lung cancer (NSCLC) with tumor size ≤ 2 cm, the prognostic significance of the number of removed lymph nodes (NLNs) through different surgical methods remains unclear. To determine the association of NLNs with cancer-specific survival (CSS) and overall survival (OS) in patients with stage IA NSCLC with tumor size ≤ 2 cm who underwent different lung surgeries. We retrospectively enrolled 7293 patients from the Surveillance, Epidemiology and End Results database. Median NLNs was used to classify the patients into two groups: group A with NLNs ≤ 5 and group B with NLNs > 5. Propensity score matching (PSM) was performed to decrease selection bias. Kaplan–Meier analysis and Cox regression analysis were performed to identify the association between NLNs and survival outcomes. Group B had better survival than group A in the unmatched cohort and matched cohort (all P < 0.05). Multivariable analyses revealed that the NLNs significantly affected CSS and OS of eligible cases in the unmatched cohort and matched cohort. Additionally, we found that the NLNs was a protective prognostic predictor of OS for patients who underwent wedge resection, segmental resection, or lobectomy. The NLNs was a protective prognostic factor in NSCLC patients with tumor size ≤ 2 cm. We demonstrated that patients with > 5 NLNs in the cohort of wedge resection, segmental resection, or lobectomy exhibited a significantly better OS.
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影响因子：
4.6
作者：
Ding, Hongdou;Wang, Haifeng;Jiang, Gening
通讯作者：
Jiang, Gening
影响因子：
4.6
作者：
Wolf, Andrea S.;Richards, William G.;Swanson, Scott J.
通讯作者：
Swanson, Scott J.
淋巴结的数量与病理淋巴结非小细胞肺癌中长期死亡率风险最大相关的淋巴结数量。
影响因子：
4.6
作者：
Osarogiagbon, Raymond U.;Ogbata, Obiageli;Yu, Xinhua
通讯作者：
Yu, Xinhua
影响因子：
20.4
作者：
Suzuki, Kenji;Koike, Teruaki;Kato, Harubumi
通讯作者：
Kato, Harubumi
DOI：
10.1016/j.jtcvs.2011.10.045
发表时间：
2012-04-01
影响因子：
6
作者：
Nomori, Hiroaki;Mori, Takeshi;Suzuki, Makoto
通讯作者：
Suzuki, Makoto